Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Jan 9;13(1):14-16.
doi: 10.1158/2159-8290.CD-22-1212.

Covalent Rescue of Mutant p53

David P Lane  1 , Chandra S Verma  2   3   4
Affiliations
Editorial

Covalent Rescue of Mutant p53

David P Lane et al. Cancer Discov. .

Abstract

p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p. 56 (3).

PubMed Disclaimer

Comment on

MeSH terms

Substances