Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Jan 9;13(1):19-22.
doi: 10.1158/2159-8290.CD-22-1199.

Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers

Adrienne D Cox  1   2   3 , Jenny P-Y Ting  3   4 , Channing J Der  2   3
Affiliations
Editorial

Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers

Adrienne D Cox et al. Cancer Discov. .

Abstract

In this issue, Hattori and colleagues capitalized on targeted small-molecule covalent inhibitors of one KRAS mutant with a G12C substitution and of other oncoproteins to create drug-peptide conjugates that serve as cancer neoantigens that prompt an immune response to oncogene-mutant cancer cells. This immunotherapy strategy can serve as an effective approach to overcome the treatment-induced resistance that limits the effectiveness of essentially all small molecule-based targeted anticancer drugs. See related article by Hattori et al., p. 132 (9).

PubMed Disclaimer

Comment on

Publication types

Substances

LinkOut - more resources