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. 2023 Jan-Jun:826:111813.
doi: 10.1016/j.mrfmmm.2022.111813. Epub 2022 Dec 31.

Association between DNA repair capacity and body mass index in women

Ian Crespo-Orta  1 , Carmen Ortiz  2 , Jarline Encarnación  2 , Erick Suárez  3 , Jaime Matta  4
Affiliations

Association between DNA repair capacity and body mass index in women

Ian Crespo-Orta et al. Mutat Res. 2023 Jan-Jun.

Abstract

Objective: Examine whether DNA repair capacity (DRC) levels are associated with body mass index (BMI) in adult women.

Design and participants: A nested study composed of 539 women without breast cancer (BC) from a case-control BC study in addition to 104 that were recruited later for a total of 643.

Measurements: DRC levels were measured in lymphocytes using a host-cell reactivation assay with a luciferase reporter gene damaged by UVC. This assay measures the efficiency of nucleotide excision repair (NER). Log-binomial regression model was used. The prevalence ratio (PR) was used to evaluate the magnitude of the association between the BMI and DRC levels. An assessment of interaction terms was performed with the likelihood ratio test. The confounding effect was assessed by comparing the point estimates of the crude and adjusted PR.

Results: The 75th percentiles of DRC levels of the women with a BMI between 18 and 25 and > 25 showed statistically significant differences. The prevalence of a DRC ≤ 5 % among women with BMI > 25 is 1.24 (95 % CI: 1.03, 1.48) times the prevalence of having a DRC ≤ 5 % among the women with BMI ≤ 25 after adjustments for different covariates. This excess was statistically significant (p < 0.05). Women with a family history of cancer had an estimated PR of 1.25 (95 % CI, 0.87-1.39; P ≥ 0.05); and women with no family history of cancer, the estimated PR was 1.6 (95 % CI, 1.14-2.22; p ≤ 0.05).

Conclusions: Women with BMI > 25 tend to have lower DRC levels. When having a family history of cancer, the PR of low DRC levels in overweight/obese individuals was not statistically significant. However, the PR of low levels of DRC in overweight/obese individuals with no family history of cancer was statistically significant.

Keywords: Body mass index; DNA repair capacity; Lymphocytes; Women.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.
DRC distribution by body mass index (BMI) strata. The left panel shows the distribution of DRC values in women with normal BMI. The right panel shows BMI values in overweight/obese women. Numbers in parenthesis represent the (25th percentile and 75th percentile) values, respectively.
See this image and copyright information in PMC

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