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. 2023 May;79(5):1635-1649.
doi: 10.1002/ps.7352. Epub 2023 Mar 1.

The novel pyridazine pyrazolecarboxamide insecticide dimpropyridaz inhibits chordotonal organ function upstream of TRPV channels

Christian Spalthoff  1 , Vincent L Salgado  2 , Narayanan Balu  2 , Michael D David  2 , Philip Hehlert  1 , Huazhang Huang  2 , John E Jones  2 , Ramani Kandasamy  2 , Gabriel A Knudsen  2 , Katherine R Lelito  2 , James B Machamer  2 , Alexandre Nesterov  2 , Michael Tomalski  2 , Gregory D Wahl  2 , Barbara J Wedel  2 , Martin C Göpfert  1
Affiliations

The novel pyridazine pyrazolecarboxamide insecticide dimpropyridaz inhibits chordotonal organ function upstream of TRPV channels

Christian Spalthoff et al. Pest Manag Sci. 2023 May.

Abstract

Background: Pyridazine pyrazolecarboxamides (PPCs) are a novel insecticide class discovered and optimized at BASF. Dimpropyridaz is the first PPC to be submitted for registration and controls many aphid species as well as whiteflies and other piercing-sucking insects.

Results: Dimpropyridaz and other tertiary amide PPCs are proinsecticides that are converted in vivo into secondary amide active forms by N-dealkylation. Active secondary amide metabolites of PPCs potently inhibit the function of insect chordotonal neurons. Unlike Group 9 and 29 insecticides, which hyperactivate chordotonal neurons and increase Ca2+ levels, active metabolites of PPCs silence chordotonal neurons and decrease intracellular Ca2+ levels. Whereas the effects of Group 9 and 29 insecticides require TRPV (Transient Receptor Potential Vanilloid) channels, PPCs act in a TRPV-independent fashion, without compromising cellular responses to Group 9 and 29 insecticides, placing the molecular PPC target upstream of TRPVs.

Conclusions: PPCs are a new class of chordotonal organ modulator insecticide for control of piercing-sucking pests. Dimpropyridaz is a PPC proinsecticide that is activated in target insects to secondary amide forms that inhibit the firing of chordotonal organs. The inhibition occurs at a site upstream of TRPVs and is TRPV-independent, providing a novel mode of action for resistance management. © 2023 BASF Corporation. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Keywords: Afidopyropen; Bemisia tabaci; Drosophila melanogaster; PPC; Periplaneta americana; flonicamid; nicotinamide; pymetrozine; pyrifluquinazon.

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References

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