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. 2023 Sep 1;30(5):320-335.
doi: 10.1097/PAP.0000000000000393. Epub 2023 Jan 10.

Melanoma and Glioblastoma-Not a Serendipitous Association

Kei Shing Oh  1 , Meera Mahalingam  2
Affiliations

Melanoma and Glioblastoma-Not a Serendipitous Association

Kei Shing Oh et al. Adv Anat Pathol. .

Abstract

Recently, we came across a patient with malignant melanoma and primary glioblastoma. Given this, we parsed the literature to ascertain the relationship, if any, between these 2 malignancies. We begin with a brief overview of melanoma and glioma in isolation followed by a chronologic overview of case reports and epidemiologic studies documenting both neoplasms. This is followed by studies detailing genetic abnormalities common to both malignancies with a view to identifying unifying genetic targets for therapeutic strategies as well as to explore the possibility of a putative association and an inherited cancer susceptibility trait. From a scientific perspective, we believe we have provided evidence favoring an association between melanoma and glioma. Future studies that include documentation of additional cases, as well as a detailed molecular analyses, will lend credence to our hypothesis that the co-occurrence of these 2 conditions is likely not serendipitous.

Keywords: genetics; glioblastoma; glioma; melanoma; melanoma-astrocytoma syndrome.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

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