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. 1987 Jul;31(7):1147-9.
doi: 10.1128/AAC.31.7.1147.

Effect of roxithromycin on acute toxoplasmosis in mice

H R Chang  1 , J C Pechere
Affiliations

Effect of roxithromycin on acute toxoplasmosis in mice

H R Chang et al. Antimicrob Agents Chemother. 1987 Jul.

Abstract

Roxithromycin effectively treated acute peritoneal murine toxoplasmosis. After five doses, starting 24 h after challenge, the 100 and 50% survival doses were 540 and 336 mg/kg per day, respectively. After 14 doses, starting 3 h after challenge, the 50% survival dose was 360 mg/kg per day. Toxoplasma gondii was recovered from the brain in 59 and 28% of surviving mice treated with 5 and 14 doses, respectively.

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