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. 2022 Dec:(6):122-126.

[Molecular genetic predictors of the efficacy and safety of tamsulosin therapy]

[Article in Russian]
S P Abdullaev, M N Shatokhin, O V Teodorovich, D A Sychev
  • PMID: 36625625

[Molecular genetic predictors of the efficacy and safety of tamsulosin therapy]

[Article in Russian]
S P Abdullaev et al. Urologiia. 2022 Dec.

Abstract

Individual differences in efficacy and safety of drugs between patients are a significant problem in modern pharmacotherapy. The bodys pharmacological response to the administration of a particular drug is determined by multiple factors, where up to 50% of the variability of the pharmacological response may be determined by the genetic variability of the body. The article presents an up-to-date review of the data on genetic polymorphisms influencing the efficacy and safety of tamsulosin therapy in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia.

Keywords: BPH; CYP2D6; CYP3A4; LUTS; tamsulosin.

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