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Review
. 2022 Dec 9;101(49):e31990.
doi: 10.1097/MD.0000000000031990.

Crosstalk between YY1 and lncRNAs in cancer: A review

Xiao-Li Wang  1 , Jing Li, Yan-Hua Cao
Affiliations
Review

Crosstalk between YY1 and lncRNAs in cancer: A review

Xiao-Li Wang et al. Medicine (Baltimore). .

Abstract

Transcription factor YY1 is an important regulator of many pathways in tumor cell growth, prognosis, epithelial-mesenchymal transition, invasion, and resistance to chemotherapy. These effects lead to upregulation of YY1 associated with poor outcomes in many tumors. Growing research evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the regulatory network of YY1. YY1 can regulate lncRNA, and serve as the regulatory molecule of YY1, and lncRNA and YY1 even form a feedback loop. In this review, we summarize the relevant mechanisms of the interaction between YY1 and noncoding RNAs during tumor progression, which will provide a possible theoretical basis for the clinical treatment of tumors.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
YY1 regulates the molecular mechanism of lncRNAs. lncRNAs = long non-coding RNAs.
Figure 2.
Figure 2.
Crosstalk between YY1 and lncRNAs in cancer. (A) lncRNA regulates YY1 networks. (B) Feedback loops between YY1 and lncRNAs. lncRNAs = long non-coding RNAs.
See this image and copyright information in PMC

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