Can a mucosal microbiota signature predict disease severity, survival, and disease recurrence in PSC?
- PMID: 36626635
- DOI: 10.1097/HEP.0000000000000021
Can a mucosal microbiota signature predict disease severity, survival, and disease recurrence in PSC?
Comment on
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A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation.Hepatology. 2023 Mar 1;77(3):715-728. doi: 10.1002/hep.32773. Epub 2023 Feb 17. Hepatology. 2023. PMID: 36056902 Free PMC article.
References
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- Hole MJ, Kaasen Jørgensen K, Holm K, Braadland PR, Meyer-Myklestad MH, Medhus AW, et al. A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation. Hepatology. 2023;77:715–728.
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- Hov JR, Karlsen TH. The microbiome in primary sclerosing cholangitis: current evidence and potential concepts. Semin Liver Dis. 2017;37:314–331.
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- Hartmann P. The microbiome in hepatobiliary and intestinal disease. Front Physiol. 2022;13. doi: 10.3389/fphys.2022.893074 - DOI
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- Nakamoto N, Sasaki N, Aoki R, Miyamoto K, Suda W, Teratani T, et al. Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis. Nat Microbiol. 2019;4:492–503.
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- Kummen M, Thingholm LB, Rühlemann MC, Holm K, Hansen SH, Moitinho-Silva L, et al. Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis. Gastroenterology. 2021;160:1784–1798.e1780.
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