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Review
. 2023 Feb 3;22(2):287-301.
doi: 10.1021/acs.jproteome.2c00637. Epub 2023 Jan 10.

Proteomics Standards Initiative at Twenty Years: Current Activities and Future Work

Eric W Deutsch  1 , Juan Antonio Vizcaíno  2 , Andrew R Jones  3 , Pierre-Alain Binz  4 , Henry Lam  5 , Joshua Klein  6 , Wout Bittremieux  7   8 , Yasset Perez-Riverol  2 , David L Tabb  9 , Mathias Walzer  2 , Sylvie Ricard-Blum  10 , Henning Hermjakob  2 , Steffen Neumann  11   12 , Tytus D Mak  13 , Shin Kawano  14   15   16 , Luis Mendoza  1 , Tim Van Den Bossche  17   18 , Ralf Gabriels  17   18 , Nuno Bandeira  7   19 , Jeremy Carver  19 , Benjamin Pullman  19 , Zhi Sun  1 , Nils Hoffmann  20 , Jim Shofstahl  21 , Yunping Zhu  22 , Luana Licata  23   24 , Federica Quaglia  25   26 , Silvio C E Tosatto  26 , Sandra E Orchard  2
Affiliations
Review

Proteomics Standards Initiative at Twenty Years: Current Activities and Future Work

Eric W Deutsch et al. J Proteome Res. .

Abstract

The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) has been successfully developing guidelines, data formats, and controlled vocabularies (CVs) for the proteomics community and other fields supported by mass spectrometry since its inception 20 years ago. Here we describe the general operation of the PSI, including its leadership, working groups, yearly workshops, and the document process by which proposals are thoroughly and publicly reviewed in order to be ratified as PSI standards. We briefly describe the current state of the many existing PSI standards, some of which remain the same as when originally developed, some of which have undergone subsequent revisions, and some of which have become obsolete. Then the set of proposals currently being developed are described, with an open call to the community for participation in the forging of the next generation of standards. Finally, we describe some synergies and collaborations with other organizations and look to the future in how the PSI will continue to promote the open sharing of data and thus accelerate the progress of the field of proteomics.

Keywords: Human Proteome Organization; Proteomics Standards Initiative; mass spectrometry; molecular interactions; proteomics; standards.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Overview of the formats developed by the Molecular Interactions Working Group and their relationships to other components in the community. Logo courtesy of IMEx.
Figure 2
Figure 2
Overview of the formats of the Mass Spectrometry Working Group and the Proteome Informatics Working Group and their relationships to other components in the community. Logo courtesy of the Proteomics Standards Initiative and ProteomeXchange.
See this image and copyright information in PMC

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