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. 2021 Jul 22:8:96-104.
doi: 10.33393/grhta.2021.2237. eCollection 2021 Jan-Dec.

Analisi di Budget Impact della formulazione depot di buprenorfina a rilascio prolungato per la gestione di pazienti affetti da disturbo da uso di oppiacei

[Article in Italian]
Michele Basile  1   2 , Lorenzo Somaini  3 , Americo Cicchetti  1   2
Affiliations

Analisi di Budget Impact della formulazione depot di buprenorfina a rilascio prolungato per la gestione di pazienti affetti da disturbo da uso di oppiacei

[Article in Italian]
Michele Basile et al. Glob Reg Health Technol Assess. .

Abstract

Background:: Opioid use disorder (OUD) is a disorder associated with significant rate of morbidity and mortality. Frequent clinic attendance for supervised consumption of sublingual buprenorphine is common. Prolonged-release buprenorphine (PRB) allows a management based on weekly or monthly subcutaneous injections, thus limiting the burdens of clinic attendance and the risks associated with sublingual formulations.

Objective:: To determine the price level of PRB that allows to obtain a neutral impact from the point of view of the economic resources absorbed, in comparison with the alternatives currently available in the Italian context for the management of patients suffering from OUD.

Methods:: The analysis assumes a daily PRB cost of € 8.526 (neutral cost). The analysis aims to determine the economic impact associated with the introduction of PRB in the Italian context for the management of OUD patients. Results are expressed in terms of differential resources absorbed in the alternative scenarios. A one-way sensitivity analysis was also carried out to test the robustness of the results.

Results:: The introduction of PRB implies an increase in the drug acquisition costs over the 5-year time horizon of € 23,016,194.61: such costs are fully compensated by the other cost driver considered in the analysis (drug tests provided, health professionals’ time destined to the provision of the treatment, indirect costs, for savings equal to € 7,255,602.59, € 10,714,320.08 and € 5,046,271.94 respectively) demonstrating its effectiveness in particular by an organizational point of view. Lower price levels for PRB would imply significant savings for the SSN.

Conclusions:: PRB resulted to be associated to a lower level of resources’ absorption in the Italian sector as compared with the available alternatives thus allowing to re-allocate health founds to other fields of the care sector ensuring greater safety for patients and a decreased misuse and diversion rate.

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Conflict of interest statement

Conflict of interest: The authors declare no conflict of interest.

Figures

Fig. 1 -
Fig. 1 -
Rappresentazione grafica dell’analisi differenziale per voce di spesa “Scenario senza PRB” vs “Scenario con PRB”.
Fig. 2 -
Fig. 2 -
Analisi di sensibilità univariata.
See this image and copyright information in PMC

References

    1. Wermeling DP. Review of naloxone safety for opioid overdose: practical considerations for new technology and expanded public access. Ther Adv Drug Saf. 2015;6(1):20–31. doi: 10.1177/2042098614564776. PubMed - DOI - PMC - PubMed
    1. Lozano R, Naghavi M, Foreman K et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–2128. doi: 10.1016/S0140-6736(12)61728-0. PubMed - DOI - PMC - PubMed
    1. Fischer B, Rehm J, Patra J, Cruz MF. Changes in illicit opioid use across Canada. CMAJ. 2006;175(11):1385–1385. doi: 10.1503/cmaj.060729. PubMed - DOI - PMC - PubMed
    1. Fischer B, Cruz MF, Rehm J. Illicit opioid use and its key characteristics: a select overview and evidence from a Canadian multisite cohort of illicit opioid users (OPICAN). Can J Psychiatry. 2006;51(10):624–634. doi: 10.1177/070674370605101002. PubMed - DOI - PubMed
    1. Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN. Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. CMAJ. 2009;181(12):891–896. doi: 10.1503/cmaj.090784. PubMed - DOI - PMC - PubMed

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