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. 2020 Dec 10:7:101-108.
doi: 10.33393/grhta.2020.2130. eCollection 2020 Jan-Dec.

Il burden economico dell’inappropriatezza prescrittiva nella gestione dell’osteoartrite in Italia

[Article in Italian]
Michele Basile  1   2 , Filippo Rumi  1   2 , Marco Palmeri  1   2 , Ivano Mattozzi  3 , Lamberto Manzoli  4 , Massimo Mammucari  5 , Sergio Gigliotti  6 , Roberto Bernabei  7 , Americo Cicchetti  1   2
Affiliations

Il burden economico dell’inappropriatezza prescrittiva nella gestione dell’osteoartrite in Italia

[Article in Italian]
Michele Basile et al. Glob Reg Health Technol Assess. .

Abstract

Introduction:: Osteoarthritis (OA) is a common chronic joint disease characterized by pain, deformity, instability, reduction of motion and function. It is one of the main causes of disability in older adults, affecting about 10% of men and 18% of women over the age of sixty. There are several Guidelines that support the general clinical decision-making process. However, it is necessary to define an integrated management model for patients with OA to ensure an appropriate and quality healthcare.

Methods:: The objective of the analysis is to determine the economic burden linked to the prevalence and incidence of OA in the acute and chronic phases from the perspective of the National Health Service (NHS) and the entire society. A comparison was made between the management according to the clinical practice and the appropriate management according to National and International Guidelines, determining for each scenario the level of resources absorbed.

Results:: Patients who started a nonsteroidal anti-inflammatory drug (NSAID)-based therapy in clinical practice resulted in a higher absorption of resources of €363.87 than the same patient managed by referring to National and International Guidelines.

Conclusions:: OA is associated with a high economic burden and it is a priority problem for public health internationally. The savings resulting from our research, if generalized to the entire Italian population, would lead to a significant reduction of OA economic burden, thus allowing a reallocation of the available resources to other NHS’ sectors.

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Conflict of interest statement

Conflict of interest: The authors declare that there is no conflict of interest.

Figures

Fig. 1 -
Fig. 1 -
Costo medio paziente per approccio terapeutico d’esordio a 2, 6, 12 mesi dall’inizio della gestione farmacologica dell’osteoartrite. COX-2 = ciclossigenasi-2; FANS = farmaci antinfiammatori non steroidei.
Fig. 2 -
Fig. 2 -
Differenziale di risorse assorbite per la gestione di un paziente affetto da osteoartrite su base annuale (Pratica Clinica vs Linee Guida). COX-2 = ciclossigenasi-2; FANS = farmaci antinfiammatori non steroidei.
Figure A -
Figure A -
Revisione di letteratura. Flowchart
Figure B -
Figure B -
Struttura del modello di determinazione del burden economico dell’inappropriatezza prescrittiva nella gestione dell’osteoartrite
See this image and copyright information in PMC

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