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. 2020 Nov 6:7:92-100.
doi: 10.33393/grhta.2020.2138. eCollection 2020 Jan-Dec.

Costo-utilità di dalbavancina versus standard of care (SoC) in pazienti con ABSSSI non severa in Italia

[Article in Italian]
Andrea Marcellusi  1   2 , Chiara Bini  1 , Maria A Rotundo  1 , Rosario Cultrera  3 , Francesco S Mennini  1   2
Affiliations

Costo-utilità di dalbavancina versus standard of care (SoC) in pazienti con ABSSSI non severa in Italia

[Article in Italian]
Andrea Marcellusi et al. Glob Reg Health Technol Assess. .

Abstract

Introduction:: Acute Bacterial Skin and Skin Structure Infections (ABSSSIs) include all complicated skin and soft tissue infections. The aim of this study was to conduct a cost-utility analysis to compare dalbavancin with standard antibiotic therapies for the management of non-severe ABSSSIs from the National Health Service (NHS) perspective.

Methods:: A probabilistic decision tree model was developed considering a 30-days follow-up to simulate the therapeutic pathway of a patient treated with dalbavancin or Standard of Care (SoC). The model considered three mutually exclusive health states: a) discharge of patients from the emergency department, b) discharge of patients after one night from admission, c) discharge after 24 or 36 hours from admission. A one-way deterministic sensitivity analysis and a probabilistic sensitivity analysis were conducted.

Results:: The analysis showed that the use of dalbavancin in patients with non-severe ABSSSI compared to SoC could generate a reduction in costs (– € 291.6 per patient treated) and an increase in QALYs (+0.0018 per patient treated). In 99.7% of the simulations carried out, dalbavancin was dominant compared to the SoC. Considering a threshold for the willingness to pay of € 30,000 for QALY gained, the minimum level of efficacy of dalbavancin so that the treatment can be considered cost-effective compared to the SoC was equal to 69.4%.

Conclusions:: The analysis showed that dalbavancin may represent a cost-effective option compared to SoC for the treatment of patients with non-severe ABSSSI.

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Conflict of interest statement

Conflict of interest: The authors declare they have no conflict of interest related to the article.

Figures

Fig. 1 -
Fig. 1 -
Albero decisionale tratto dallo studio europeo (17).
Fig. 2 -
Fig. 2 -
Piano di costo-efficacia.
Fig. 3 -
Fig. 3 -
Analisi di break-even point.
Fig. 4 -
Fig. 4 -
Grafico tornado.
See this image and copyright information in PMC

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