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Case Reports
. 2022 Dec 7;14(12):e32287.
doi: 10.7759/cureus.32287. eCollection 2022 Dec.

Parry Romberg Syndrome in a Young Ghanaian: A Case Report and a Literature Review

Klenam Dzefi-Tettey  1 , Emmanuel K Edzie  2 , Mark-Young Seadey  3 , Edmund K Brakohiapa  4 , Samuel Asiamah  5 , Simpson K Mensah  5 , Kafui K Kekeshie  6 , Caroline E Ntiamoah-Koufie  7 , Denisson K Agala  5 , Franklin Acheampong  8
Affiliations
Case Reports

Parry Romberg Syndrome in a Young Ghanaian: A Case Report and a Literature Review

Klenam Dzefi-Tettey et al. Cureus. .

Abstract

Parry Romberg syndrome (PRS), also known as progressive hemifacial atrophy, is a very rare self-limiting disease, which affects the skin and subcutaneous tissues, underlying musculature, cartilage, and bony structures of one half of the face with a resultant hemiatrophy and alopecia areata. It presents in children and young adults, with a slow progression of the atrophy for several years, and then becomes stable. Magnetic resonance imaging (MRI) or computed tomography (CT) scan of the cranium demonstrates the radiological feature of hemiatrophy very clearly. We report a case of PRS in a nine-year-old girl with characteristic features which was diagnosed based on medical history, clinical signs, and radiological findings on cranial CT scan and MRI.

Keywords: computed tomography scan; ghana; magnetic resonance imaging; parry romberg syndrome; progressive hemifacial atrophy.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. A child with Parry Romberg syndrome with (a) and (b) showing normal facial appearance (no facial asymmetry); however, (b) shows the beginning of hair loss and subtle hypopigmentation of the left frontal scalp (white arrow); (c) and (d) show hypopigmentation, progressive left facial hemiatrophy, small left nostril, loss of hair of the left eyebrow, and alopecia areata
Figure 2
Figure 2. Head CT scan 3D volume rendering (a), axial bone window (b), coronal bone window (c), and axial brain window (d) showing thinning of the left frontal and parietal bones, subcutaneous tissues/fat, and reduction in the left nasal cavity. Subtle effacement of the sulci of the left frontal lobe is also seen.
CT, computed tomography; 3D, three-dimensional.
Figure 3
Figure 3. MRI of the head, axial unenhanced T1W image, showing subtle effacement of the sulci of the left frontal lobe and thinning of the ipsilateral subcutaneous scalp tissues (a), coronal T1W image post gadolinium enhancement showing a marked reduction in the left nasal cavity and subtle effacement of the sulci (b), axial SWI revealed no micro hemorrhages or aneurysms (c), the left para sagittal MRI (d) also showed thinning of the subcutaneous frontal scalp tissues and subtle frontal lobe atrophy compared with the contralateral right parasagittal image (e).
MRI, magnetic resonance imaging; T1W, T1-weighted; SWI, susceptibility-weighted imaging.
See this image and copyright information in PMC

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