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. 1987 Jul;60(5):370-5.
doi: 10.1007/BF00295757.

Renal handling of cadmium and cadmium-metallothionein: studies on the isolated perfused rat kidney

J Abel  1 , D Höhr, H J Schurek
Affiliations

Renal handling of cadmium and cadmium-metallothionein: studies on the isolated perfused rat kidney

J Abel et al. Arch Toxicol. 1987 Jul.

Abstract

The isolated kidney perfusion model was used to study the uptake of Cd and metallothionein (MT)-complexed Cd. Cd2+ at concentrations above 40 nM strongly depressed the glomerular filtration rate (GFR), whereas MT-complexed Cd (Cd-MT) at concentrations of 0.8-920 nM had no effect on the GFR. In contrast to Cd2+, Cd-MT was readily reabsorbed by the kidney and uptake saturation for Cd-MT occurred at 240 nM. The maximal transport rate for Cd-MT calculated in this study was 18 pmoles Cd-MT . g-1 . min-1. The accumulation of Cd in the kidney was more efficient in the experiment using Cd-MT, in which case the Cd kidney contents were about 2-4 times higher than compared to CdCl2.

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References

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