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. 2022 Sep 19:9:91-98.
doi: 10.33393/grhta.2022.2413. eCollection 2022 Jan-Dec.

Analisi di impatto di budget di un nuovo sistema di cura in pazienti affetti da malattia di Parkinson

[Article in Italian]
Chiara Bini  1 , Francesco Saverio Mennini  1   2 , Andrea Marcellusi  1 , Martina Paoletti  1   3 , Carlo Tomino  4
Affiliations

Analisi di impatto di budget di un nuovo sistema di cura in pazienti affetti da malattia di Parkinson

[Article in Italian]
Chiara Bini et al. Glob Reg Health Technol Assess. .

Abstract

Objective:: To estimate the economic impact of the introduction of a new care system based on apomorphine and Patient Support Program for motor fluctuations (“on-off” phenomena) in patients with Parkinson’s disease which are not sufficiently controlled by oral anti-Parkinson medication in Italy.

Method:: A Budget Impact model was developed to evaluate the new care system in patients with Parkinson’s disease over a 3-years’ time horizon. The comparator treatments included in the analysis were treatments based on apomorphine and levodopa + carbidopa. The analysis was conducted from a National Health Service (NHS) perspective. Costs included in the analysis were acquisition costs and device costs. A deterministic sensitivity analysis was carried out to evaluate the uncertainty of the parameters used. A break-even analysis was conducted to identify the minimum number of subjects that would need to be treated with the new care system to obtain a positive Budget Impact (World With – World Without = 0).

Results:: The analysis shows that the introduction of the new care system based on apomorphine could generate a cost saving incurred by the NHS of over € 5.7 million in 3 years. Break-even analysis shows that if it were possible to intercept with the new treatment at least 9 patients treated with apomorphine, there would not be an increase in costs for the NHS.

Conclusion:: The new care system would respond to the unmet needs of patients with Parkinson’s disease by generating a reduction in the expenditure incurred by NHS.

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Conflict of interest statement

Conflict of interest: The Authors declare no conflict of interest.

Figures

Fig. 1 -
Fig. 1 -
Composizione della spesa totale a tre anni – Italia.
Fig. 2 -
Fig. 2 -
Analisi di sensitività a una via – stime cumulate anno 3.
Fig. 3 -
Fig. 3 -
Analisi di break-even.
See this image and copyright information in PMC

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