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. 2023 Feb 20;62(9):e202218072.
doi: 10.1002/anie.202218072. Epub 2023 Jan 24.

Synthetic Receptors with Micromolar Affinity for Chloride in Water

Sylvain Sudan  1 , Damien W Chen  1 , Cesare Berton  1 , Farzaneh Fadaei-Tirani  1 , Kay Severin  1
Affiliations

Synthetic Receptors with Micromolar Affinity for Chloride in Water

Sylvain Sudan et al. Angew Chem Int Ed Engl. .

Abstract

A water-soluble coordination cage was obtained by reaction of Pd(NO3 )2 with a 1,3-di(pyridin-3-yl)benzene ligand featuring a short PEG chain. The cavity of the metal-organic cage contains one nitrate anion, which is readily replaced by chloride. The apparent association constant for chloride binding in buffered aqueous solution is Ka =1.8(±0.1)×105 M-1 . This value is significantly higher than what has been reported for other macrocyclic chloride receptors. The heavier halides Br- and I- compete with binding or self-assembly, but the receptor displays very good selectivity over common anions such as phosphate, acetate, carbonate, and sulfate. A further increase of the chloride binding affinity by a factor of 3 was achieved using a fluorinated dipyridyl ligand.

Keywords: Anion Receptor; Cage; Chloride; Self-Assembly; Supramolecular Chemistry.

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