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. 2023 Jan 25:1239:340712.
doi: 10.1016/j.aca.2022.340712. Epub 2022 Dec 7.

Development of a QuEChERS method for simultaneous analysis of 3-Monochloropropane-1,2-diol monoesters and Glycidyl esters in edible oils and margarine by LC-APCI-MS/MS

Jorge A Custodio-Mendoza  1 , Raquel Sendón  2 , Ana Rodríguez-Bernaldo de Quirós  2 , Rosa A Lorenzo  3 , Antonia M Carro  4
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Free article

Development of a QuEChERS method for simultaneous analysis of 3-Monochloropropane-1,2-diol monoesters and Glycidyl esters in edible oils and margarine by LC-APCI-MS/MS

Jorge A Custodio-Mendoza et al. Anal Chim Acta. .
Free article

Abstract

A simple, fast and effective direct method based on HPLC-APCI-QqQ-MS/MS has been developed to simultaneously determine four 3-monochloropropane-1,2-diol monoesters (3-MCPDE) esterified with palmitic, linoleic, stearic, and oleic acid, and two glycidyl esters (GE) with palmitic and oleic acid in margarine and olive oil using a QuEChERS approach. Factors affecting the efficiency of the extraction process were assessed, including type and amount of salt, extraction solvent, test portion amount, and clean-up sorbent. The analytical method was validated according to Food and Drug Administration (FDA) guidelines using matrix-matched calibration with internal standards and showed good results in terms of linearity (r2 > 0.9992), accuracy (80<Recovery<120%), and precision (RSD<15%). The method was successfully applied for the first time to 11 margarine samples for simultaneous analysis of 3-MCPDE and GE.

Keywords: 3-MCPD; APCI; Food contaminants; Glycidyl; HPLC method; QuEChERS.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: A. M. Carro reports financial support was provided by Spanish Ministry of Science, Innovation, and Universities.

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