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. 2023 Jan;93(1-2):257-262.
doi: 10.1111/ans.18264. Epub 2023 Jan 11.

Surgery for phyllodes tumour of the breast. What should be surgical margins?

Mustafa Tukenmez  1 , Baran Mollavelioglu  2 , Semen Onder  3 , Selman Emiroglu  1 , Mehmet Velidedeoglu  4 , Sefa Ergun  4 , Neslihan Cabioglu  1 , Mahmut Muslumanoglu  1
Affiliations

Surgery for phyllodes tumour of the breast. What should be surgical margins?

Mustafa Tukenmez et al. ANZ J Surg. 2023 Jan.

Abstract

Backgrounds: Optimal and tailored surgical treatment of phyllodes tumour(PT) of the breast is controversial. This study aims to determine the appropriate surgical margin in the treatment of PT.

Methodology: The data of 132 patients who underwent breast surgery with the diagnosis of PT at the Breast Unit of Istanbul Faculty of Medicine from 2000 to 2022 were retrospectively reviewed.

Results: Median age was 38 and patients with benign PT were younger than others(median age was 34, 44, and 43 for benign, borderline, and malignant, respectively) (P = 0.001). Local recurrence was observed in 7 (5.3%) patients, systemic recurrence was observed in 3 (2.3%) patients, and disease-related death was observed in 2 (1.5%) patients. Local recurrence occurred in 1.4% (n = 1) of benign tumours, 8.3% (n = 2) of borderline tumours, and 10.3% (n = 4) of malignant tumours. All of the systemic recurrences and deaths were seen in the malignant group. The local recurrence rate was found to be higher in borderline and malignant tumours with surgical margins less than 10 mm (44.4% versus 3.7%, P = 0.003), and tumours larger than 5 cm (11.8% versus 1.3%, P = 0.015). In comparison, there was no correlation between the surgical margin proximity, tumour diameter, and local recurrence rates in benign PT (P > 0.05).

Conclusion: According to our findings, negative surgical margins seem to be sufficient in the treatment of benign phyllodes tumours. Furthermore at least 1 cm negative surgical margins must be achieved for malignant and borderline phyllodes tumours to avoid local recurrence.

Keywords: Local recurrence; Surgical margin; phyllodes tumour.

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