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Comment
. 2023 Feb;49(2):241-243.
doi: 10.1007/s00134-022-06905-9. Epub 2023 Jan 11.

The effect of vasopressin and hydrocortisone on cytokine trajectories

Charlotte Cleasby  1 , Tim Marshall  1   2 , Anthony C Gordon  1 , David B Antcliffe  3 ; Sepsis Cytokine Trajectory Investigators
Collaborators, Affiliations
Comment

The effect of vasopressin and hydrocortisone on cytokine trajectories

Charlotte Cleasby et al. Intensive Care Med. 2023 Feb.
No abstract available

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Conflict of interest statement

ACG reports that he has consulted for GSK and 30 Respiratory, with funds paid to his institution. Other authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Comparison of cytokine trajectories for patients receiving A hydrocortisone (red) or placebo (blue) and B combinations of noradrenaline (grey outline, dashed line) or vasopressin (black outline, solid line) with either hydrocortisone (red) or placebo (blue) for monocyte chemoattractant protein-1 (MCP-1), Interleukin-6 (IL-6) and interferon gamma-induced protein-10 (IP10). Data are displayed as box plots of the natural log of the cytokine concentrations (pg/ml) for each day after enrolment into the study with median values connected by a coloured line to illustrate trajectory. P values are those from comparing models with and without an interaction term between day and drug/drug combination after correction for multiple comparisons using the Benjamini–Hochberg procedure. These results were unchanged in the sensitivity analyses performed
See this image and copyright information in PMC

Comment on

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