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. 2023 Feb 9;388(6):567-569.
doi: 10.1056/NEJMc2213907. Epub 2023 Jan 11.

Antibody Response to Omicron BA.4-BA.5 Bivalent Booster

Qian Wang  1 , Anthony Bowen  1 , Riccardo Valdez  2 , Carmen Gherasim  2 , Aubree Gordon  2 , Lihong Liu  3 , David D Ho  3
Affiliations

Antibody Response to Omicron BA.4-BA.5 Bivalent Booster

Qian Wang et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Neutralization Profiles of Serum Samples against SARS-CoV-2 Variants and Other Sarbecoviruses.
Panel A shows the 50% inhibitory dilution (ID50) titers of serum samples obtained from participants who had received either three or four doses of a monovalent messenger RNA (mRNA) vaccine (three-dose and four-dose monovalent groups), those who had BA.4–BA.5 breakthrough infection after three or four doses of monovalent mRNA vaccine (convalescent group), and those who had received three doses of a monovalent mRNA vaccine followed by one dose of a bivalent vaccine targeting BA.4–BA.5 variants (bivalent-booster group). Panel B shows the antibody response induced by a fourth dose of the original monovalent mRNA vaccine as compared with a fourth dose of a BA.4–BA.5 bivalent booster. Fourth doses of the mRNA-1273 vaccines are indicated by bold symbols; nonbold symbols indicate fourth doses of the BNT162b2 vaccines. Between-group comparisons were performed with the use of Mann–Whitney tests. In Panels A and B, values above the data points indicate the geometric mean ID50 titers, the dotted horizontal lines indicate the lower limit of detection of the assay, and 𝙸 bars indicate the standard deviation.
See this image and copyright information in PMC

References

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    1. Food and Drug Administration. Coronavirus (COVID-19) update: FDA authorizes Moderna, Pfizer-BioNTech bivalent COVID-19 vaccines for use as a booster dose. August 31, 2022. (https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19...).
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Publication types

Supplementary concepts