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Comment
. 2023 Jan 10;56(1):1-3.
doi: 10.1016/j.immuni.2022.12.015.

GATA4 as a maestro of gut regionalization

Licia Torres  1 , Ana M C Faria  2
Affiliations
Free article
Comment

GATA4 as a maestro of gut regionalization

Licia Torres et al. Immunity. .
Free article

Abstract

How gut regionalization impacts microbiota and immunity is unclear. In this issue of Immunity, Earley et al. show that jejumal GATA4 expression controls bacteria colonization through retinol metabolism and IgA production. This metabolic-immune axis limits intestinal Th17 responses and immunopathology.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.
    Earley ZM, Lisicka W, Sifakis JJ, Aguirre-Gamboa R, Kowalczyk A, Barlow JT, Shaw DG, Discepolo V, Tan IL, Gona S, Ernest JD, Matzinger P, Barreiro LB, Morgun A, Bendelac A, Ismagilov RF, Shulzhenko N, Riesenfeld SJ, Jabri B. Earley ZM, et al. Immunity. 2023 Jan 10;56(1):43-57.e10. doi: 10.1016/j.immuni.2022.12.009. Immunity. 2023. PMID: 36630917 Free PMC article.

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