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Comment
. 2023 Jan 10;56(1):3-5.
doi: 10.1016/j.immuni.2022.12.011.

Eating macrophages for a healthy anti-NASH meal

Affiliations
Comment

Eating macrophages for a healthy anti-NASH meal

Yun Sok Lee et al. Immunity. .

Abstract

Nonalcoholic steatohepatitis (NASH) is a common liver disease involving interactions between a variety of liver cell types. In this issue of Immunity, Wang et al. show that efferocytosis of dying lipid-laden hepatocytes by hepatic macrophages protects against the development of NASH.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.
Regulation of TREM2 expression in hepatic macrophages and the effect of membrane-bound TREM2 on efferocytosis of steatotic hepatocytes and the development of NASH (Wang et al.)

Comment on

References

    1. Deczkowska A, Weiner A, and Amit I (2020). The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway. Cell 181, 1207–1217. 10.1016/j.cell.2020.05.003. - DOI - PubMed
    1. Feuerbach D, Schindler P, Barske C, Joller S, Beng-Louka E, Worringer KA, Kommineni S, Kaykas A, Ho DJ, Ye C, et al. (2017). ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157. Neurosci Lett 660, 109–114. 10.1016/j.neulet.2017.09.034. - DOI - PubMed
    1. Gao H, Jin Z, Bandyopadhyay G, Cunha ERK, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, et al. (2022). MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab 34, 978–990 e974. 10.1016/j.cmet.2022.05.008. - DOI - PMC - PubMed
    1. Hendrikx T, Porsch F, Kiss MG, Rajcic D, Papac-Milicevic N, Hoebinger C, Goederle L, Hladik A, Shaw LE, Horstmann H, et al. (2022). Soluble TREM2 levels reflect the recruitment and expansion of TREM2(+) macrophages that localize to fibrotic areas and limit NASH. J Hepatol 77, 1373–1385. 10.1016/j.jhep.2022.06.004. - DOI - PubMed
    1. Hou J, Zhang J, Cui P, Zhou Y, Liu C, Wu X, Ji Y, Wang S, Cheng B, Ye H, et al. (2021). TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis. J Clin Invest 131. 10.1172/JCI135197. - DOI - PMC - PubMed

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