Eating macrophages for a healthy anti-NASH meal
- PMID: 36630915
- PMCID: PMC10441811
- DOI: 10.1016/j.immuni.2022.12.011
Eating macrophages for a healthy anti-NASH meal
Abstract
Nonalcoholic steatohepatitis (NASH) is a common liver disease involving interactions between a variety of liver cell types. In this issue of Immunity, Wang et al. show that efferocytosis of dying lipid-laden hepatocytes by hepatic macrophages protects against the development of NASH.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Figures
Comment on
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Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.Immunity. 2023 Jan 10;56(1):58-77.e11. doi: 10.1016/j.immuni.2022.11.013. Epub 2022 Dec 14. Immunity. 2023. PMID: 36521495 Free PMC article.
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