Potential conflicts of interest. K. N. A. reports grants or contracts from the National Institutes of Health (NIH) and consulting fees paid to the author from TrioHealth for serving on the Scientific Advisory Board. K. A. G. initiated this work during her role as the Chief Medical and Scientific Officer of the All of Us Research Program. K. A. G. also reports grants or contracts paid to their institution from Octapharma, US Department of Defense's Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense; NIH National Institute of Allergy and Infectious Diseases (3R01AI152078-01S1); NIH National Center for Advancing Translational Sciences (U24TR001609-S3 and UL1TR00309); Mental Wellness Foundation; HealthNetwork Foundation; Bloomberg Philanthropies; Moriah Fund; Shear Family Foundation; and the State of Maryland Defense Health Agency (W911QY2090012). Additional royalties or licenses from UptoDate were paid directly to K. A. G., and additional consulting fees were paid directly to K. A. G. from Spark HealthCare, Teach for America, and Aspen Institute. K. A. G. serves as an uncompensated participant of Pfizer's Scientific Advisory Board. S. D. S. reports no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.