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. 1987 Jun 1;244(2):493-6.
doi: 10.1042/bj2440493.

Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions

A Spät  1 , G L Lukács, I Eberhardt, L Kiesel, B Runnebaum
Affiliations

Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions

A Spät et al. Biochem J. .

Abstract

Bovine anterior-pituitary microsomal fractions exhibit high-affinity, saturable and reversible binding of inositol 1,4,5-[32P]trisphosphate; 50% of the labelled ligand is displaced by 3.5 nM-inositol 1,4,5-trisphosphate. 0.5 microM-inositol 1,4-bisphosphate and 10 microM-ATP. Inositol 1,4,5-trisphosphate induces the release of Ca2+ from the microsomal vesicles (half-maximal effect at 290 nM), and its action is potentiated by inositol tetrakisphosphate (half-maximal effect at 4 microM).

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