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. 2023 Jan 11;18(1):3.
doi: 10.1186/s13024-023-00594-8.

Alzheimer's disease: targeting the peripheral circulation

Zhi-Hao Liu  1   2   3 , Yan-Jiang Wang  1   2   3   4   5   6 , Xian-Le Bu  7   8   9   10
Affiliations

Alzheimer's disease: targeting the peripheral circulation

Zhi-Hao Liu et al. Mol Neurodegener. .
No abstract available

Keywords: Alzheimer’s disease; Aβ clearance; Blood exchange; Systemic factors.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The potential mechanisms of whole blood exchange as an intervention for Alzheimer’s disease. A) Young wild-type (Wt) mice have abundant young immune cells and protective factors but fewer harmful factors and no Aβ in the blood. B) Elderly transgenic mice with Alzheimer’s disease (AD) have fewer young immune cells and protective factors and abundant harmful factors and Aβ in the blood. C) Schematic diagram of whole blood exchange. D) Transplantation of blood from young Wt mice into elderly AD mice could enhance the peripheral clearance of Aβ, increase the number of young immune cells and protective factors, reduce the number of harmful factors, and ultimately alleviate brain Aβ deposition. E) Key for the symbols used in this figure
See this image and copyright information in PMC

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