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Review
. 2023 Jan 3;3(1):26-30.
doi: 10.21873/cdp.10175. eCollection 2023 Jan-Feb.

The Landscape of Single Nucleotide Polymorphisms in Papillary Thyroid Carcinoma

Efthymios Kyrodimos  1 , Aristeidis Chrysovergis  1 , Nicholas Mastronikolis  2 , George Papanastasiou  3 , Evangelos Tsiambas  4 , Despoina Spyropoulou  5 , Spyros Katsinis  6 , Arezina Manoli  6 , Sotirios Papouliakos  7 , Pavlos Pantos  1 , Vasileios Ragos  3 , Dimitrios Peschos  8 , Vasileios Papanikolaou  1
Affiliations
Review

The Landscape of Single Nucleotide Polymorphisms in Papillary Thyroid Carcinoma

Efthymios Kyrodimos et al. Cancer Diagn Progn. .

Abstract

Thyroid carcinoma represents a leading malignancy among those derived from human endocrine systems. It comprises a variety of different histological subtypes, including mainly papillary carcinoma, follicular carcinoma, anaplastic carcinoma, and medullar carcinoma. A broad spectrum of genetic imbalances, comprising gross chromosomal (polysomy/aneuploidy) and specific gene (mutations, amplifications, deletions) alterations, has been reported. Interestingly, the role of isolated, specific gene polymorphisms, especially of the single nucleotide polymorphism (SNP) type, in thyroid carcinoma is under investigation. SNPs are the most common genetic variations in the genome. The current molecular review focuses on the impact of specific SNPs on the biological behavior of papillary thyroid carcinoma in their carriers.

Keywords: DNA; Thyroid; carcinoma; gene; review; single nucleotide polymorphisms.

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Conflict of interest statement

The Authors have no conflicts of interest to declare.

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