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Review
. 2023 May;365(5):457-461.
doi: 10.1016/j.amjms.2023.01.002. Epub 2023 Jan 9.

Portal vein thrombosis as the presenting manifestation of JAK2 positive myeloproliferative neoplasm

Won Jin Jeon  1 , Akhil Mehta  1 , Jessica Hudson  2 , Dani Ran Castillo  3 , Jun Wang  2 , Anthony Nguyen  4 , Mojtaba Akhtari  5
Affiliations
Review

Portal vein thrombosis as the presenting manifestation of JAK2 positive myeloproliferative neoplasm

Won Jin Jeon et al. Am J Med Sci. 2023 May.

Abstract

Deep venous thrombosis (DVT) is a complication of myeloproliferative neoplasms (MPNs). However, DVTs in unusual sites such as portal vein thrombosis (PVT) are rare and may be the first clinical manifestation of occult MPNs. There is a need for increasing awareness of such manifestations; so, here we discuss a patient who presented with new portal vein thrombosis, underwent further studies, was ultimately diagnosed with JAK2 positive MPN, and started on appropriate treatment with improvement of thrombosis and controlled hematocrit.

Keywords: Deep vein thrombosis; JAK2; Myeloproliferative neoplasms; Philadelphia chromosome; Polycythemia vera.

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Conflict of interest statement

Declaration of Competing Interest All authors do not declare any conflict of interest. In addition, all the authors are aware of and approve the manuscript as submitted to this journal.

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