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Editorial
. 2023 Jan 12;141(2):129-130.
doi: 10.1182/blood.2022018791.

(De)ironing out sickle cell disease

Nupur K Das  1 , Yatrik M Shah  1
Affiliations
Editorial

(De)ironing out sickle cell disease

Nupur K Das et al. Blood. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Iron restriction attenuates SCD pathologies in a mouse model. Iron plays a critical role in the pathogenesis of mouse SCD. Dietary iron restriction ameliorates neutrophil aging, gut epithelial disruption, and microbiota alteration, all of which impact SCD morbidities.
See this image and copyright information in PMC

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References

    1. Li H, Kazmi JS, Lee SK, et al. Dietary iron restriction protects against vaso-occlusion and organ damage in murine sickle cell disease. Blood. 2023;141(2):194–199. - PMC - PubMed
    1. Ware RE, de Montalembert M, Tshilolo L, Abboud MR. Sickle cell disease. Lancet. 2017;390(10091):311–323. - PubMed
    1. Manwani D, Frenette PS. Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Blood. 2013;122(24):3892–3898. - PMC - PubMed
    1. Das N, Xie L, Ramakrishnan SK, Campbell A, Rivella S, Shah YM. Intestine-specific disruption of hypoxia-inducible factor (HIF)-2alpha improves anemia in sickle cell disease. J Biol Chem. 2015;290(39):23523–23527. - PMC - PubMed
    1. Gardenghi S, Ramos P, Marongiu MF, et al. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice. J Clin Invest. 2010;120(12):4466–4477. - PMC - PubMed