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. 2023 Jan;23(1):53-61.
doi: 10.1080/14737159.2023.2168190. Epub 2023 Jan 18.

The expression and mutation of BRCA1/2 genes in ovarian cancer: a global systematic study

Dinh-Toi Chu  1   2 , Mai Vu Ngoc Suong  1 , Hue Vu Thi  1   2 , Thuy-Duong Vu  1 , Manh-Hung Nguyen  1 , Vijai Singh  3
Affiliations

The expression and mutation of BRCA1/2 genes in ovarian cancer: a global systematic study

Dinh-Toi Chu et al. Expert Rev Mol Diagn. 2023 Jan.

Abstract

Introduction: This systematic review was designed to summarize the findings on expression and mutation of BRCA1/2 genes in ovarian cancer (OC) patients, focusing on mutation detection technology and taking clinical decisions for better treatment.

Areas covered: We conducted a systematic review by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses document selection guidelines for the document selection process and the PICOT standard for developing the keywords to search for. A total of 5729 publications were included, and 50 articles were put into the final screening. The results showed that Next-Generation Sequencing was a breakthrough technology in detecting Breast Cancer 1/2 (BRCA1/2) gene mutations because of its efficacy and affordability. Other technologies are also being applied now for mutation detection. The most prominent associations of BRCA1/2 gene mutations were age, heredity, and family history. Furthermore, mutations of BRCA1/2 could improve survival rate and overall survival. There is no sufficient study available to conclude a systematic analysis for the expression of BRCA1/2 gene in OC.

Expert opinion: Research will continue to develop more diagnostic techniques based on the expression and mutation of BCRA1/2 genes for OC in the near future.

Keywords: BRCA1/2 gene in ovarian cancer; The mutation of BRCA1/2; the expression of BRCA1/2.

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