Could the control of O-GlcNAcylation play a key role in cardiac remodeling?

Affiliations

¹ Department of Cardiovascular Medicine, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan. s-toyoda@dokkyomed.ac.jp.
² Department of Cardiology, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.

Editorial

Shigeru Toyoda et al. Hypertens Res. 2023 Mar.

. 2023 Mar;46(3):765-767.

doi: 10.1038/s41440-023-01171-8. Epub 2023 Jan 13.

¹ Department of Cardiovascular Medicine, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan. s-toyoda@dokkyomed.ac.jp.
² Department of Cardiology, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.

No abstract available

Keywords: Cardiac remodeling; Intermittent hypoxia; O-GlcNAcylation.

Comment on

Augmented O-GlcNAcylation attenuates intermittent hypoxia-induced cardiac remodeling through the suppression of NFAT and NF-κB activities in mice.
Nakagawa T, Furukawa Y, Hayashi T, Nomura A, Yokoe S, Moriwaki K, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M. Nakagawa T, et al. Hypertens Res. 2019 Dec;42(12):1858-1871. doi: 10.1038/s41440-019-0311-x. Epub 2019 Aug 13. Hypertens Res. 2019. PMID: 31409917
Augmented O-GlcNAcylation exacerbates right ventricular dysfunction and remodeling via enhancement of hypertrophy, mitophagy, and fibrosis in mice exposed to long-term intermittent hypoxia.
Yokoe S, Hayashi T, Nakagawa T, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M. Yokoe S, et al. Hypertens Res. 2023 Mar;46(3):667-678. doi: 10.1038/s41440-022-01088-8. Epub 2022 Nov 14. Hypertens Res. 2023. PMID: 36376492

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