Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Jun;21(2):208-220.
doi: 10.1111/vco.12878. Epub 2023 Jan 29.

Sentinel lymph node mapping with computed tomography lymphography for mast cell tumours and a comparison between regional and sentinel lymph node histological status: Sixty-two cases

Erica Ilaria Ferraris  1 , Matteo Olimpo  1 , Davide Giacobino  1 , Luca Manassero  1 , Selina Iussich  1 , Elena Lardone  1 , Mariateresa Camerino  1 , Paolo Buracco  1 , Emanuela Maria Morello  1
Affiliations
Free article
Case Reports

Sentinel lymph node mapping with computed tomography lymphography for mast cell tumours and a comparison between regional and sentinel lymph node histological status: Sixty-two cases

Erica Ilaria Ferraris et al. Vet Comp Oncol. 2023 Jun.
Free article

Abstract

It is known that the regional lymph node (RLN) may not correspond to the sentinel lymph node (SLN) (the first lymph node draining the tumour), and many diagnostic techniques have recently been aimed at its detection. Although lymphoscintigraphy is the gold standard in both human and veterinary medicine for SLN mapping, it is relatively unavailable in veterinary medicine due to costs and difficult management of the radiotracer. This prospective study evaluated, as a first aim, the feasibility and sensitivity of the computed tomography lymphography (CTL) in detecting the SLN in 62 mast cell tumours (MCTs). The second aim was to evaluate the accuracy of the CTL in identifying the most representative lymph node of the patient's lymphatic status; the histological status of the SNL was compared with that of the RLN, to see in how many cases the patient's stage would have changed according to the RLN. When the RLN turned out to be also the SLN it was decided to excise, as a control LN, the one localised in the neighbourhood of the MCT (neighbouring lymph node; NLN). The detection rate was 90%, with failure of SLN identification in six cases. In 18 (32%) of 56 MCTs with a diagnostic CTL, the SLN did not correspond to the RLN. Forty-five MCTs were surgically removed, together with their corresponding SLN and RLN/NLN. Since the clinical stage of the patient would have changed in only 7% of cases, CTL is a reliable method of detecting the SLN and, for staging purposes, there is no need to remove other LNs.

Keywords: computed tomographic lymphography; dog; lymphadenectomy; mast cell tumour; regional lymph node; sentinel lymph node.

PubMed Disclaimer

References

REFERENCES

    1. Weishaar KM, Thamm DH, Worley DR, Kamstock DA. Correlation of nodal mast cell with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis. J Comp Pathol. 2014;151(4):329-338.
    1. Williams LE, Packer RA. Association between lymph node size and metastasis in dogs with oral malignant melanoma: 100 cases (1987-2001). J Am Vet Med Assoc. 2003;222:1234-1236.
    1. Grimes JA, Matz BM, Christopherson PW, et al. Agreement between cytology and histopathology for regional lymph node metastasis in dogs with melanocytic neoplasms. Vet Pathol. 2017;54:579-587.
    1. Fournier Q, Cazzini P, Bavcar S, Pecceu E, Ballber C, Elders R. Investigation of the utility of lymph node fine-needle aspiration cytology for the staging of malignant solid tumours in dogs. Vet Clin Pathol. 2018;47:489-500.
    1. Gilson SD. Clinical management of the regional lymph node. Vet Clin N Am Small Anim Pract. 1995;25:149-167.

Publication types

MeSH terms