Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Nov 8;16(3):595-600.
doi: 10.1159/000525270. eCollection 2022 Sep-Dec.

Recurrent Cholangitis Secondary to a Traumatic Biliary Neuroma

Nadin Y Rayyan  1 , Razan N Aburumman  1 , Luma Altaweel  1 , Nadwa Albustami  1   2 , Mousa A Al-Abbadi  1   2 , Yaser M Rayyan  1   3
Affiliations
Case Reports

Recurrent Cholangitis Secondary to a Traumatic Biliary Neuroma

Nadin Y Rayyan et al. Case Rep Gastroenterol. .

Abstract

Biliary amputation neuroma is rare and difficult to diagnose preoperatively due to diversity of clinical presentation and a lack of awareness among healthcare providers. We present a case of biliary neuroma arising from a recent laparoscopic cholecystectomy, complicated by bile leak and recurrent cholangitis. An extensive review of the literature was performed, closely examining related etiology, trends in age, clinical symptomology, and time to presentation. The role of surgery compared to an endoscopic approach in diagnosis has been reviewed. Physicians are urged to remain mindful of malignant biliary strictures as they may easily mimic and misguide the diagnosis of a traumatic biliary neuroma.

Keywords: Biliary neuroma; Cholangitis; Obstructive jaundice.

PubMed Disclaimer

Conflict of interest statement

Authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
ERCP cholangiogram with short CHD stricture (arrow head), CHD stone (long arrow), with upstream dilatation of the intrahepatic ducts. CHD, common hepatic duct.
Fig. 2
Fig. 2
a Low power microscopic view showing the tumor-like nerve bundles with no evidence of atypia, mitosis, or necrosis (hematoxylin and eosin ×200). b Higher microscopic view showing the nerve bundles in clusters compressing in between the fibrovascular tissue (hematoxylin and eosin ×400).
Fig. 3
Fig. 3
Immunohistochemical stain for S100 revealing strong immunoreactivity of the tumor cell and showing histological evidence of compression of the CBD epithelium (arrow).
See this image and copyright information in PMC

References

    1. Zabaglo M, Dreyer MA., Neuroma . Treasure Island, FL: StatPearls Publishing; 2022. In StatPearls [Internet] - PubMed
    1. Husseinoff D. Ueber einem Fall von Wucherung des Nervengewebes nach wiederholten Operationen der Gallenga nge. Zbl Allg Path. 1928;43:344–8.
    1. Pickens A, Vickers SM, Brown KL, Reddy VV, Thompson JA. An unusual etiology of biliary hilar obstruction and the potential role of acidic fibroblast growth factor in the development of a biliary neuroma. Am Surg. 1999 Jan;65((1)):47–51. - PubMed
    1. Lalchandani P, Korn A, Lu JG, French SW, Hou L, Chen KT. Traumatic bile duct neuroma presenting with acute cholangitis a case report and review of literature. Ann Hepatobiliary Pancreat Surg. 2019 Aug;23((3)):282–285. Epub 2019 Aug 30. - PMC - PubMed
    1. Comfort MW, Walters W. Intermittent jaundice due to neuroma of cystic and common bile ducts. Ann Surg. 1931;93((6)):1142–1145. - PMC - PubMed

Publication types