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. 2023 Jan 13;408(1):24.
doi: 10.1007/s00423-023-02759-x.

Hepatic artery-related complications after live donor liver transplantation

Viniyendra Pamecha  1 , Piyush Kumar Sinha  2 , Amar Mukund  3 , Nilesh Sadashiv Patil  2 , Nihar Mohapatra  2 , Shalini Thapar  4 , Ashok Choudhury  5 , Gaurav Sindwani  6 , Anubhav Harshit Kumar  2 , Sahil Gupta  2
Affiliations

Hepatic artery-related complications after live donor liver transplantation

Viniyendra Pamecha et al. Langenbecks Arch Surg. .

Erratum in

Abstract

Background: Hepatic artery-related complications (HARC) after live donor liver transplantation (LDLT) is associated with high morbidity and mortality rate.

Methods: Prospectively maintained data from July 2011 to September 2020 was analyzed for etiology, detection, management, and outcome of HARC.

Results: Six hundred fifty-seven LDLT (adult 572/pediatrics 85) were performed during the study period. Twenty-one (3.2%) patient developed HARC; 16 (2.4%) hepatic artery thrombosis (HAT) and 5 (0.76%) non-thrombotic hepatic artery complication (NTHAC). Ninety percent (19/21) HARC were asymptomatic and detected on protocol Doppler. Median time to detection was day 4 (range - 1 to 35), which included 18 early (within 7 days) vs 3 late incidents. Only one pediatric patient had HAT. Seven patients underwent surgical revascularization, 11 had endovascular intervention and 3 with attenuated flow required only systemic anticoagulation. All NTHAC survived without any sequelae. Revascularization was successful in 81% (13/16) with HAT. Biliary complications were seen in 5 (23.8%); four were managed successfully. Overall mortality was 14.8% (3/21). The 1-year and 5-year survival were similar to those who did not develop HARC (80.9% vs 84.2%, p = 0.27 and 71.4% vs 75.19%, p = 0.36 respectively) but biliary complications were significantly higher (23.8% vs 14.2%, p = 0.03). On multivariate analysis, clockwise technique of arterial reconstruction was associated with decreased risk of HAT (1.7% vs 4.1% (p value - 0.003)).

Conclusion: Technical refinement, early detection, and revascularization can achieve good outcome in patients with HARC after LDLT.

Keywords: Endovascular intervention; Hepatic artery related complications; Live donor liver transplant; Surgical revascularization.

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References

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