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Review
. 2023 Feb:735:109518.
doi: 10.1016/j.abb.2023.109518. Epub 2023 Jan 10.

The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase

Paul F Fitzpatrick  1
Affiliations
Review

The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase

Paul F Fitzpatrick. Arch Biochem Biophys. 2023 Feb.

Abstract

The aromatic amino acid hydroxylases phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase are non-heme iron enzymes that catalyze key physiological reactions. This review discusses the present understanding of the common catalytic mechanism of these enzymes and recent advances in understanding the relationship between their structures and their regulation.

Keywords: Allostery; Catecholamines; Non-heme iron; Phenylketonuria; Phosphorylation.

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