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Review
. 2023 Jan 13;27(1):15.
doi: 10.1186/s13054-022-04290-9.

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Affiliations
Review

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Rui Moreno et al. Crit Care. .

Abstract

The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients. Changes in clinical practice over the last few decades, with new interventions and a greater focus on non-invasive monitoring systems, mean it is time to update the SOFA score. As a first step in this process, we propose some possible new variables that could be included in a SOFA 2.0. By so doing, we hope to stimulate debate and discussion to move toward a new, properly validated score that will be fit for modern practice.

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Conflict of interest statement

RM has no competing interest to declare relevant to this article. AR has no competing interest to declare relevant to this article. LP has no competing interest to declare relevant to this article. GH has no competing interest to declare relevant to this article. JT has no competing interest to declare relevant to this article. HBG received funding from Gilead Sciences, Inc. to serve on COVID therapeutics advisory board (not related to this work). MT has no competing interest to declare relevant to this article. CMC is an Associate Editor of Critical Care—he has no other competing interest to declare relevant to this article. SNM has no competing interest to declare relevant to this article. Mervyn S has no competing interest to declare relevant to this article. ER has no competing interest to declare relevant to this article. HCP served on the surviving sepsis campaign guidelines and is physician-lead for a Michigan statewide sepsis consortium. This manuscript does not represent the views of the Department of Veterans Affairs or the US government. This material is the result of work supported with resources and use of facilities at the Ann Arbor VA Medical Center. Marcio S is founder and equity shareholder of Epimed Solutions®, which commercializes the Epimed Monitor System®, a cloud-based software for ICU management and benchmarking. JFT has no competing interest to declare relevant to this article. DWdL has no competing interest to declare relevant to this article. CJ has no competing interest to declare relevant to this article. JJDW has no competing interest to declare relevant to this article. GSM has no competing interest to declare relevant to this article. CS has no competing interest to declare relevant to this article. EA has no competing interest to declare relevant to this article. AR has no competing interest to declare relevant to this article. TF has no competing interest to declare relevant to this article. ASM has no competing interest to declare relevant to this article. JLV is Editor-in-Chief of Critical Care—he has no other competing interest to declare relevant to this article.

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References

    1. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22:707–10. - PubMed
    1. Vincent JL, De Mendonca A, Cantraine F, Moreno R, Takala J, Suter PM et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on “sepsis-related problems” of the European Society of Intensive Care Medicine. Crit Care Med. 1998;26:1793–800. - PubMed
    1. Khanna A, English SW, Wang XS, Ham K, Tumlin J, Szerlip H, et al. Angiotensin II for the treatment of vasodilatory shock. N Engl J Med. 2017;377:419–430. doi: 10.1056/NEJMoa1704154. - DOI - PubMed
    1. Hernandez G, Ospina-Tascon GA, Damiani LP, Estenssoro E, Dubin A, Hurtado J, et al. Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: the ANDROMEDA-SHOCK randomized clinical trial. JAMA. 2019;321:654–664. doi: 10.1001/jama.2019.0071. - DOI - PMC - PubMed
    1. van Zanten AR, Sztark F, Kaisers UX, Zielmann S, Felbinger TW, Sablotzki AR, et al. High-protein enteral nutrition enriched with immune-modulating nutrients vs standard high-protein enteral nutrition and nosocomial infections in the ICU: a randomized clinical trial. JAMA. 2014;312:514–524. doi: 10.1001/jama.2014.7698. - DOI - PubMed