The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Rui Moreno^{1

2}, Andrew Rhodes³, Lise Piquilloud⁴, Glenn Hernandez⁵, Jukka Takala⁶, Hayley B Gershengorn⁷, Miguel Tavares⁸, Craig M Coopersmith⁹, Sheila N Myatra¹⁰, Mervyn Singer¹¹, Ederlon Rezende¹², Hallie C Prescott^{13

14}, Márcio Soares¹⁵, Jean-François Timsit¹⁶, Dylan W de Lange¹⁷, Christian Jung¹⁸, Jan J De Waele¹⁹, Greg S Martin²⁰, Charlotte Summers²¹, Elie Azoulay²², Tomoko Fujii²³, Anthony S McLean²⁴, Jean-Louis Vincent²⁵

Affiliations

¹ Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Faculdade de Ciências Médicas de Lisboa, Nova Médical School, Lisbon, Portugal.
² Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
³ Adult Critical Care, St. George's University Hospitals NHS Foundation Trust, St. George's University of London, London, UK.
⁴ Adult Intensive Care Unit, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
⁵ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
⁶ Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
⁷ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
⁸ Department of Anesthesiology, Critical Care, and Emergency Medicine, Hospital de Santo António - Centro Hospitalar Universitário Do Porto, Porto, Portugal.
⁹ Department of Surgery, Emory Critical Care Center, Atlanta, GA, 30322, USA.
¹⁰ Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
¹¹ Division of Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.
¹² Hospital Do Servidor Público Estadual "Francisco Morato de Oliveira", São Paulo, SP, Brasil.
¹³ Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
¹⁴ VA Center for Clinical Management Research, HSR&D Center of Innovation, Ann Arbor, MI, USA.
¹⁵ Department of Critical Care, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
¹⁶ Medical and Infectious Diseases Intensive Care Unit (MI2), AP-HP, Bichat Hospital, Paris, France.
¹⁷ Department of Intensive Care Medicine, University Medical Centre Utrecht, University Utrecht, Utrecht, The Netherlands.
¹⁸ Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
¹⁹ Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.
²⁰ Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University and Grady Memorial Hospital, Atlanta, GA, USA.
²¹ Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
²² Medical Intensive Care Unit, Famirea Study Group, Paris, France.
²³ Intensive Care Unit, Jikei University Hospital, Tokyo, Japan.
²⁴ Department of Intensive Care Medicine, Nepean Hospital, Kingswood, NSW, Australia.
²⁵ Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, 1070, Brussels, Belgium. jlvincent@intensive.org.

PMID: 36639780
PMCID: PMC9837980
DOI: 10.1186/s13054-022-04290-9

Review

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Rui Moreno et al. Crit Care. 2023.

. 2023 Jan 13;27(1):15.

doi: 10.1186/s13054-022-04290-9.

Authors

Affiliations

¹ Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Faculdade de Ciências Médicas de Lisboa, Nova Médical School, Lisbon, Portugal.
² Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
³ Adult Critical Care, St. George's University Hospitals NHS Foundation Trust, St. George's University of London, London, UK.
⁴ Adult Intensive Care Unit, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
⁵ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
⁶ Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
⁷ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
⁸ Department of Anesthesiology, Critical Care, and Emergency Medicine, Hospital de Santo António - Centro Hospitalar Universitário Do Porto, Porto, Portugal.
⁹ Department of Surgery, Emory Critical Care Center, Atlanta, GA, 30322, USA.
¹⁰ Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
¹¹ Division of Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.
¹² Hospital Do Servidor Público Estadual "Francisco Morato de Oliveira", São Paulo, SP, Brasil.
¹³ Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
¹⁴ VA Center for Clinical Management Research, HSR&D Center of Innovation, Ann Arbor, MI, USA.
¹⁵ Department of Critical Care, D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
¹⁶ Medical and Infectious Diseases Intensive Care Unit (MI2), AP-HP, Bichat Hospital, Paris, France.
¹⁷ Department of Intensive Care Medicine, University Medical Centre Utrecht, University Utrecht, Utrecht, The Netherlands.
¹⁸ Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
¹⁹ Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.
²⁰ Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University and Grady Memorial Hospital, Atlanta, GA, USA.
²¹ Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
²² Medical Intensive Care Unit, Famirea Study Group, Paris, France.
²³ Intensive Care Unit, Jikei University Hospital, Tokyo, Japan.
²⁴ Department of Intensive Care Medicine, Nepean Hospital, Kingswood, NSW, Australia.
²⁵ Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, 1070, Brussels, Belgium. jlvincent@intensive.org.

PMID: 36639780
PMCID: PMC9837980
DOI: 10.1186/s13054-022-04290-9

Abstract

The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients. Changes in clinical practice over the last few decades, with new interventions and a greater focus on non-invasive monitoring systems, mean it is time to update the SOFA score. As a first step in this process, we propose some possible new variables that could be included in a SOFA 2.0. By so doing, we hope to stimulate debate and discussion to move toward a new, properly validated score that will be fit for modern practice.

PubMed Disclaimer

Conflict of interest statement

RM has no competing interest to declare relevant to this article. AR has no competing interest to declare relevant to this article. LP has no competing interest to declare relevant to this article. GH has no competing interest to declare relevant to this article. JT has no competing interest to declare relevant to this article. HBG received funding from Gilead Sciences, Inc. to serve on COVID therapeutics advisory board (not related to this work). MT has no competing interest to declare relevant to this article. CMC is an Associate Editor of Critical Care—he has no other competing interest to declare relevant to this article. SNM has no competing interest to declare relevant to this article. Mervyn S has no competing interest to declare relevant to this article. ER has no competing interest to declare relevant to this article. HCP served on the surviving sepsis campaign guidelines and is physician-lead for a Michigan statewide sepsis consortium. This manuscript does not represent the views of the Department of Veterans Affairs or the US government. This material is the result of work supported with resources and use of facilities at the Ann Arbor VA Medical Center. Marcio S is founder and equity shareholder of Epimed Solutions®, which commercializes the Epimed Monitor System^®, a cloud-based software for ICU management and benchmarking. JFT has no competing interest to declare relevant to this article. DWdL has no competing interest to declare relevant to this article. CJ has no competing interest to declare relevant to this article. JJDW has no competing interest to declare relevant to this article. GSM has no competing interest to declare relevant to this article. CS has no competing interest to declare relevant to this article. EA has no competing interest to declare relevant to this article. AR has no competing interest to declare relevant to this article. TF has no competing interest to declare relevant to this article. ASM has no competing interest to declare relevant to this article. JLV is Editor-in-Chief of Critical Care—he has no other competing interest to declare relevant to this article.

Comment in

Real-world inter-observer variability of the Sequential Organ Failure Assessment (SOFA) score in intensive care medicine: the time has come for an update.
Pérez-Torres D, Merino-García PA, Canas-Pérez I, Cuenca-Rubio C, Posadas-Pita GJ, Colmenero-Calleja C, Ticona-Espinoza TG, Díaz-Rodríguez C. Pérez-Torres D, et al. Crit Care. 2023 Apr 21;27(1):160. doi: 10.1186/s13054-023-04449-y. Crit Care. 2023. PMID: 37085825 Free PMC article. No abstract available.
Real-world inter-observer variability of the sequential organ failure assessment (SOFA) score in intensive care medicine: the time has come for an update: authors' reply.
Moreno R, Rhodes A, Singer M, Vincent JL; authors.. Moreno R, et al. Crit Care. 2023 May 11;27(1):182. doi: 10.1186/s13054-023-04468-9. Crit Care. 2023. PMID: 37170120 Free PMC article. No abstract available.

References

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The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Affiliations

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Authors

Affiliations

Abstract

Conflict of interest statement

Comment in

References

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