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. 2023 Feb;43(1):175-180.
doi: 10.19852/j.cnki.jtcm.20221006.002.

Effect and cerebral mechanism of moxibustion at heat-sensitized Yaoyangguan (GV3) in patients with lumbar disc herniation and myofascial pain syndrome by resting-state functionality magnetic resonance imaging: protocol for an observational study

Yang Jun  1 , Xiong Jun  1   2 , X U Shaozhong  3 , Xie Hongwu  3 , Xiang Jie  1
Affiliations

Effect and cerebral mechanism of moxibustion at heat-sensitized Yaoyangguan (GV3) in patients with lumbar disc herniation and myofascial pain syndrome by resting-state functionality magnetic resonance imaging: protocol for an observational study

Yang Jun et al. J Tradit Chin Med. 2023 Feb.

Abstract

We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan (GV3) in patients with lumbar disc herniation (LDH) and myofascial pain syndrome (MPS). In an assessor-blinded observational study, we will include 15 LDH and 15 MPS. They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan (GV3). The resting-state functionality magnetic resonance imaging image data of brain activities before and after treatment will be analyzed by mean fractional amplitude of low-frequency fluctuation, regional homogeneity analysis and brain functional connection. We select seed of first sensory cortex, second sensory cortex, insula cortex, periaqueductal gray and anterior cingulate cortex as the regions of interest to analyse the relationship between brain functional connectivity of pain-related networks and clinical data. Our study could disclose key brain targets and central response characteristics of the analgesic brain effect and the brain functional connection of heat-sensitive moxibustion.

Keywords: heat-sensitive moxibustion; lumbar disc herniation; mean fractional amplitude of low-frequency fluctuation; myofascial pain syndrome; pilot projects; point GV3 (Yaoyangguan); regional homogeneity; resting-state functionality magnetic resonance imaging.

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Figures

Figure 1
Figure 1. Flowchart of the participants
rfMRI: resting-state functionality magnetic resonance imaging; LDH: lumbar disc herniation; MPS: myofascial pain syndrome; GV3: Yaoyangguan (GV3); mfALFF: mean fractional amplitude of low-frequency fluctuation; ReHo: regional homogeneity.
Figure 2
Figure 2. Study schedule for data collection
LDH: lumbar disc herniation; MPS: myofascial pain syndrome; rfMRI: resting-state functionality magnetic resonance imaging; MPQ: mcGill pain questionnaire; M-JOA: modified Japanese orthopaedic association scale; VAS: visual visual analog scale; FABQ: fear-avoidance beliefs questionnaire.
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