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Randomized Controlled Trial
. 2023 May;16(5):e202200299.
doi: 10.1002/jbio.202200299. Epub 2023 Feb 3.

Effects of multiwavelength photobiomodulation for the treatment of traumatic soft tissue injuries associated with bone fractures: A double-blind, randomized controlled clinical trial

Frederico Carlos Jana Neto  1   2   3 , Ana Luiza Cabrera Martimbianco  4   5 , Raquel Agnelli Mesquita-Ferrari  1   6 , Sandra Kalil Bussadori  1   6 , Gustavo Porto Alves  2 , Paulo Victor Dias Almeida  2 , Felipe Guimaraes Delgado  2 , Lucas Resende Fonseca  2 , Maiara Zeni Graiff Gama  3 , Mariana Djrdjrjan Jorge  3 , Michael R Hamblin  7 , Kristianne Porta Santos Fernandes  1
Affiliations
Randomized Controlled Trial

Effects of multiwavelength photobiomodulation for the treatment of traumatic soft tissue injuries associated with bone fractures: A double-blind, randomized controlled clinical trial

Frederico Carlos Jana Neto et al. J Biophotonics. 2023 May.

Abstract

This study evaluated the efficacy and safety of multiwavelength photobiomodulation (MPBM) in healing soft tissue injuries associated with tibial and/or ankle fractures. Participants were randomized into the MPBM or control group. Primary outcome was wound healing, measured by the Bates-Jensen scale. Assessments were performed daily. Twenty-seven hospitalized adults were included. MPBM showed an improvement in the daily mean Bates-Jensen scale (MPBM 32.1 vs. control 34.2; p = 0.029), daily mean pain score change (MPBM 0.5 vs. control 0.2; p = 0.04) and occurrence of infection at the site of the external fixator pins (MPBM 15.3% vs. control 57.1%; p = 0.02). MPBM group also showed faster-wound resolution (MPBM 13.1 vs. control 23.1 days). Subgroup analysis showed improvement in the MPBM group among less severe patients on the Bates-Jensen scale (MPBM 27.4 vs. control 34.7; p = 0.0081) and mean time for wound resolution (MPBM 7.0 vs. control 14.6 days; p = 0.03). MPBM appears safe and effective in reducing wound resolution time, infection in the surgical pin sites, reported pain and time before definitive surgery.

Keywords: bone fracture; multiwavelength LED; non-pharmaceutical pain control; photobiomodulation; randomized placebo-controlled clinical trial.

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