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. 2023 Mar;34(3):693-699.
doi: 10.1111/jce.15813. Epub 2023 Jan 20.

Effect of contact force on pulsed field ablation lesions in porcine cardiac tissue

Lars Mattison  1 , Atul Verma  2 , Khaldoun G Tarakji  1 , Tobias Reichlin  3 , Gerhard Hindricks  4 , Kevin L Sack  1 , Birce Önal  1 , Megan M Schmidt  1 , Damijan Miklavčič  5 , Daniel C Sigg  1
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Free article

Effect of contact force on pulsed field ablation lesions in porcine cardiac tissue

Lars Mattison et al. J Cardiovasc Electrophysiol. 2023 Mar.
Free article

Abstract

Introduction: Contact force has been used to titrate lesion formation for radiofrequency ablation. Pulsed field ablation (PFA) is a field-based ablation technology for which limited evidence on the impact of contact force on lesion size is available.

Methods: Porcine hearts (n = 6) were perfused using a modified Langendorff set-up. A prototype focal PFA catheter attached to a force gauge was held perpendicular to the epicardium and lowered until contact was made. Contact force was recorded during each PFA delivery. Matured lesions were cross-sectioned, stained, and the lesion dimensions measured.

Results: A total of 82 lesions were evaluated with contact forces between 1.3 and 48.6 g. Mean lesion depth was 4.8 ± 0.9 mm (standard deviation), mean lesion width was 9.1 ± 1.3 mm, and mean lesion volume was 217.0 ± 96.6 mm3 . Linear regression curves showed an increase of only 0.01 mm in depth (depth = 0.01 × contact force + 4.41, R2 = 0.05), 0.03 mm in width (width = 0.03 × contact force + 8.26, R2 = 0.13) for each additional gram of contact force, and 2.20 mm3 in volume (volume = 2.20 × contact force + 162, R2 = 0.10).

Conclusion: Increasing contact force using a bipolar, biphasic focal PFA system has minimal effects on acute lesion dimensions in an isolated porcine heart model and achieving tissue contact is more important than the force with which that contact is made.

Keywords: cardiac ablation; contact force; irreversible electroporation; pulsed field ablation.

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References

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