Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar:156:103800.
doi: 10.1016/j.jri.2023.103800. Epub 2023 Jan 11.

Obesity in pregnancy is associated with macrophage influx and an upregulated GRO-alpha and IL-6 expression in the decidua

Sanja Löb  1 , Julia Knabl  2 , Aurelia Vattai  3 , Elisa Schmoeckel  4 , Christina Kuhn  5 , Johanna Mittelberger  5 , Achim Wöckel  1 , Sven Mahner  3 , Udo Jeschke  6
Affiliations

Obesity in pregnancy is associated with macrophage influx and an upregulated GRO-alpha and IL-6 expression in the decidua

Sanja Löb et al. J Reprod Immunol. 2023 Mar.

Abstract

About one third of all reproductive-aged women are affected by obesity. Maternal obesity is linked to an adverse outcome for both mother and child. The expression of the pro-inflammatory IL-6 and GRO-alpha as well as the infiltration of macrophages in the placenta of obese, non-diabetic pregnancies was examined by immunohistochemistry in comparison to the placenta of normal weight women. In obese pregnancies the influx of macrophages was significantly increased (p = 0.012). The protein expression of IL-6 and GRO-alpha was significantly elevated (p = 0.036 and p < 0.001, respectively) in the decidua of adipose females.

Keywords: GRO-alpha; IL-6; Macrophages; Obesity in pregnancy.

PubMed Disclaimer

LinkOut - more resources