BATF reprograms the tumor immune status

Tao Fan¹, Chu Xiao¹, Shan Muhammad¹, Chunxiang Li², Jie He³

Affiliations

¹ Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
² Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address: lichunxiang@cicams.ac.cn.
³ Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address: hejie@cicams.ac.cn.

PMID: 36640752
DOI: 10.1016/j.medj.2022.12.004

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BATF reprograms the tumor immune status

Tao Fan et al. Med. 2023.

Free article

. 2023 Jan 13;4(1):10-12.

doi: 10.1016/j.medj.2022.12.004.

Authors

Tao Fan¹, Chu Xiao¹, Shan Muhammad¹, Chunxiang Li², Jie He³

Affiliations

¹ Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
² Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address: lichunxiang@cicams.ac.cn.
³ Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address: hejie@cicams.ac.cn.

PMID: 36640752
DOI: 10.1016/j.medj.2022.12.004

Abstract

The AP-1 family member BATF maintains immune cell function. Two recent papers by Zhang et al.¹ and Itahashi et al.² investigated the role of this protein in cancer immunity, finding that its depletion in CAR-T cells augments anti-tumor activity and it contributes to Treg-mediated immunosuppression in the tumor microenvironment.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.
Itahashi K, Irie T, Yuda J, Kumagai S, Tanegashima T, Lin YT, Watanabe S, Goto Y, Suzuki J, Aokage K, Tsuboi M, Minami Y, Ishii G, Ohe Y, Ise W, Kurosaki T, Suzuki Y, Koyama S, Nishikawa H. Itahashi K, et al. Sci Immunol. 2022 Oct 14;7(76):eabk0957. doi: 10.1126/sciimmunol.abk0957. Epub 2022 Oct 7. Sci Immunol. 2022. PMID: 36206353
Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
Zhang X, Zhang C, Qiao M, Cheng C, Tang N, Lu S, Sun W, Xu B, Cao Y, Wei X, Wang Y, Han W, Wang H. Zhang X, et al. Cancer Cell. 2022 Nov 14;40(11):1407-1422.e7. doi: 10.1016/j.ccell.2022.09.013. Epub 2022 Oct 13. Cancer Cell. 2022. PMID: 36240777

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BATF reprograms the tumor immune status

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BATF reprograms the tumor immune status

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Conflict of interest statement

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