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. 1987 Aug 18;418(1):201-3.
doi: 10.1016/0006-8993(87)90982-6.

Hyperalgesia to heat after intradermal injection of capsaicin

D A Simone  1 , J Y Ngeow, G J Putterman, R H LaMotte
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Free article

Hyperalgesia to heat after intradermal injection of capsaicin

D A Simone et al. Brain Res. .
Free article

Abstract

Capsaicin injected intradermally into the human forearm lowered the pain threshold for heat at the injection site. Both the magnitude and duration of hyperalgesia were dose dependent over the range of 0.1-100 micrograms, given in a constant volume of 10 microliter. Thus, capsaicin may be a useful tool in studies of the neural mechanisms of hyperalgesia.

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