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Review
. 2023 Mar;68(1):1-20.
doi: 10.1007/s11686-023-00658-1. Epub 2023 Jan 16.

The Tick-Borne Pathogens: An Overview of China's Situation

Yuxuan Luan #  1   2 , Jingmin Gou #  1 , Dongjie Zhong  3 , Li Ma  1 , Chuansong Yin  1 , Minfeng Shu  2 , Guangyuan Liu  4 , Qing Lin  5   6
Affiliations
Review

The Tick-Borne Pathogens: An Overview of China's Situation

Yuxuan Luan et al. Acta Parasitol. 2023 Mar.

Abstract

Background: Ticks are important medical arthropods that can transmit hundreds of pathogens, such as parasites, bacteria, and viruses, leading to serious public health burdens worldwide. Unexplained fever is the most common clinical manifestation of tick-borne diseases. Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the surge of coronavirus disease 2019 (COVID-19) cases led to the hospital overload and fewer laboratory tests for tick-borne diseases. Therefore, it is essential to review the tick-borne pathogens and further understand tick-borne diseases.

Purpose: The geographic distribution and population of ticks in the Northern hemisphere have expanded while emerging tick-borne pathogens have been introduced to China continuously. This paper focused on the tick-borne pathogens that are threatening public health in the world. Their medical significant tick vectors, as well as the epidemiology, clinical manifestations, diagnosis, treatment, prevention, and control measures, are emphasized in this document.

Methods: In this study, all required data were collected from articles indexed in English databases, including Scopus, PubMed, Web of Science, Science Direct, and Google Scholar.

Results: Ticks presented a great threat to the economy and public health. Although both infections by tick-borne pathogens and SARS-CoV-2 have fever symptoms, the history of tick bite and its associated symptoms such as encephalitis or eschar could be helpful for the differential diagnosis. Additionally, as a carrier of vector ticks, migratory birds may play a potential role in the geographical expansion of ticks and tick-borne pathogens during seasonal migration.

Conclusion: China should assess the risk score of vector ticks and clarify the potential role of migratory birds in transmitting ticks. Additionally, the individual and collective protection, vector control, comprehensive surveillance, accurate diagnosis, and symptomatic treatment should be carried out, to meet the challenge.

Keywords: Bacteria; Parasite; Pathogen; Tick; Tick-borne pathogens; Virus.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Fig. 1
Fig. 1
Geographic distribution of Tick-borne parasite prevalence
Fig. 2
Fig. 2
Geographic distribution of Tick-borne bacteria prevalence
Fig. 3
Fig. 3
Geographic distribution of Tick-borne virus prevalence
See this image and copyright information in PMC

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References

    1. Zhao GP, Wang YX, Fan ZW, Ji Y, Liu MJ, Zhang WH, Li XL, Zhou SX, Li H, Liang S, Liu W, Yang Y, Fang LQ. Mapping ticks and tick-borne pathogens in China. Nat Commun. 2021;12:1075. doi: 10.1038/s41467-021-21375-1. - DOI - PMC - PubMed
    1. Socolovschi C, Mediannikov O, Raoult D, Parola P. The relationship between spotted fever group Rickettsiae and ixodid ticks. Vet Res. 2009;40:34. doi: 10.1051/vetres/2009017. - DOI - PMC - PubMed
    1. Kasaija PD, Estrada-Peña A, Contreras M, Kirunda H, de la Fuente J. Cattle ticks and tick-borne diseases: a review of Uganda’s situation. Ticks Tick Borne Dis. 2021;12:101756. doi: 10.1016/j.ttbdis.2021.101756. - DOI - PubMed
    1. Li Z, Liu J, Zhao S, Ma Q, Liu A, Li Y, Guan G, Luo J, Yin H. Theileria annulata Subtelomere-Encoded Variable Secreted Protein-TA05575 Binds to Bovine RBMX2. Front Cell Infect Microbiol. 2021;11:644983. doi: 10.3389/fcimb.2021.644983. - DOI - PMC - PubMed
    1. Couzin-Frankel J. Lyme disease research gets a needed boost. Science (New York, N.Y.) 2019;364:221. doi: 10.1126/science.364.6437.221. - DOI - PubMed