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Review
. 2023 Mar;53(3):e2149548.
doi: 10.1002/eji.202149548. Epub 2023 Feb 5.

Classical DC2 subsets and monocyte-derived DC: Delineating the developmental and functional relationship

Ronald A Backer  1   2 , Hans Christian Probst  2   3 , Björn E Clausen  1   2
Affiliations
Free article
Review

Classical DC2 subsets and monocyte-derived DC: Delineating the developmental and functional relationship

Ronald A Backer et al. Eur J Immunol. 2023 Mar.
Free article

Abstract

To specifically tailor immune responses to a given pathogenic threat, dendritic cells (DC) are highly heterogeneous and comprise many specialized subtypes, including conventional DC (cDC) and monocyte-derived DC (MoDC), each with distinct developmental and functional characteristics. However, the functional relationship between cDC and MoDC is not fully understood, as the overlapping phenotypes of certain type 2 cDC (cDC2) subsets and MoDC do not allow satisfactory distinction of these cells in the tissue, particularly during inflammation. However, precise cDC2 and MoDC classification is required for studies addressing how these diverse cell types control immune responses and is therefore currently one of the major interests in the field of cDC research. This review will revise murine cDC2 and MoDC biology in the steady state and under inflammatory conditions and discusses the commonalities and differences between ESAMlo cDC2, inflammatory cDC2, and MoDC and their relative contribution to the initiation, propagation, and regulation of immune responses.

Keywords: ESAMlo cDC2; inflammatory cDC2; monocyte-derived DC (MoDC).

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References

    1. Banchereau, J. and Steinman, R. M. Dendritic cells and the control of immunity. Nature. 1998. 392: 245-252.
    1. Amon, L., Lehmann, C. H. K., Baranska, A., Schoen, J., Heger, L. and Dudziak, D. Transcriptional control of dendritic cell development and functions. Int Rev Cell Mol Biol. 2019. 349: 55-151.
    1. Pakalniškytė, D. and Schraml, B. U., Tissue-Specific Diversity and Functions of Conventional Dendritic Cells. Adv. Immunol. 2017. 134: 89-135.
    1. Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira Da Costa, M. and Reis E Sousa, C., Dendritic Cells Revisited. Annu. Rev. Immunol. 2021. 39: 131-166.
    1. Eisenbarth, S. C. Dendritic cell subsets in T-cell programming: location dictates function. Nat. Rev. Immunol. 2019. 19: 89-103.

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