Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 10:11:20503121221136401.
doi: 10.1177/20503121221136401. eCollection 2023.

Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review

Safinaz M Alshiakh  1   2
Affiliations
Review

Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review

Safinaz M Alshiakh. SAGE Open Med. .

Abstract

Objective: In the Emergency Department, the physician's purpose is to rapidly and accurately diagnose the severity of a patient's condition so that proper treatment can be administered. Therefore, this study pays close attention to the association and prognostic value of blood lactate on different disease outcomes by systematically reviewing recently published studies.

Methods: The search strategy was developed based on searches in the year 2022 for potential publications including original articles, case reports, and reviews using the following web databases google scholar, PubMed, and Science Direct. A total of 25 studies were identified and reviewed extensively to evaluate the link between mortality and serum lactate levels.

Results: This literature review presents the strong association of elevated serum lactate levels with the in-hospital mortality rate among emergency department patients.

Conclusion: These findings suggest that even a moderately raised lactate level in serum can predict the severe outcome in emergency department patients suffering from different conditions. Therefore, early (at the time of administration of hospital) and periodic serum lactate value determination through different techniques and scores is of need and should become part of routine analyses in emergency department to predict and choose therapies that could benefit critically ill patients.

Keywords: Serum lactate; emergency patients; mortality; sepsis; trauma.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow diagram of research methodology.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nichol AD, Egi M, Pettila V, et al.. Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study. Crit Care 2010; 14(1): R25–R29. - PMC - PubMed
    1. Juneja D, Singh O, Dang R. Admission hyperlactatemia: causes, incidence, and impact on outcome of patients admitted in a general medical intensive care unit. J Crit Care 2011; 26(3): 316–320. - PubMed
    1. Brooks G. Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise. Fed Proc 1986; 45: 2924–2929. - PubMed
    1. Ryoo SM, Kim WY. Clinical applications of lactate testing in patients with sepsis and septic shock. J Emerg Crit Care Med 2018; 2: 14.
    1. Ferreruela M, Raurich JM, Ayestarán I, et al.. Hyperlactatemia in ICU patients: incidence, causes and associated mortality. J Crit Care 2017; 42: 200–205. - PubMed

LinkOut - more resources