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. 2023 Jan 7:19:97-107.
doi: 10.2147/NDT.S376942. eCollection 2023.

Glutathione S-Transferase M1/ T1 Polymorphisms and Schizophrenia Risk: A New Method for Quality Assessment and a Systematic Review

Hongzhou Liu #  1 , Ying Xu #  1 , Jie Peng  1
Affiliations

Glutathione S-Transferase M1/ T1 Polymorphisms and Schizophrenia Risk: A New Method for Quality Assessment and a Systematic Review

Hongzhou Liu et al. Neuropsychiatr Dis Treat. .

Abstract

Background: GST genes were reported to be involved in susceptibility to mental disorder. The results between deletions of GST genes and schizophrenia were inconclusive and confusing. Therefore, we performed this updated meta-analysis to outline the association using a new method for quality assessment.

Methods: Sixteen reported studies were selected, and the overall OR and 95% CI were calculated and analyzed by Review Manager 5.4 and STATE 12. The Newcastle-Ottawa Quality Assessment Scale (NOS) for case-control studies was rewritten to evaluate the quality of published studies, as there was no "Exposure" in these studies and other factors should be suggested to assess the quality.

Results: There was no significant association between deletions of GST genes and SZ risk (p > 0.05 in Random model). We also failed to find a significant relation between null genotypes and SZ risk in East Asian population. Based on further analysis of PCR methods, GSTM1 null was weakly associated with SZ risk in 8 studies using multiplex PCR (OR = 1.17, 95% CI = 1.00-1.37, p = 0.05), but GSTT1 null was a protective factor for SZ risk (OR = 0.73, 95% CI = 0.56-0.94, p = 0.02). When stratified by rewritten NOS stars and deductions, GSTM1 null was significantly associated with SZ risk in 9 studies with high quality (OR = 1.24, 95% CI = 1.08-1.43, p = 0.002), and in 10 studies with no deductions (OR = 1.20, 95% CI = 1.05-1.38, p = 0.007).

Conclusion: GSTM1 null genotype may be a genetic risk factor for SZ in studies using multiplex PCR and high-quality studies. However, GSTT1 null might be a protective factor. Besides, we provided a new method for quality assessment and it was useful and should be promoted in further analysis.

Keywords: GSTM1; glutathione S-transferase T1; meta-analysis; polymorphism; schizophrenia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A flow diagram of the study selection process.
Figure 2
Figure 2
Forest plot of overall studies. (A) Analysis of null genotype vs present genotype of GSTM1. P = 0.25 [Overall OR = 1.11, 95% CI = (0.93–1.32)]. (B) Analysis of null genotype vs present genotype of GSTT1. P = 0.32 [Overall OR = 0.90, 95% CI = (0.73–1.11)]. (C) Analysis of null genotype vs present genotype of GSTM1 + GSTT1. P = 0.46 [Overall OR = 1.16, 95% CI = (0.79–1.69)].
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