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. 1987 Nov 15;60(10):2419-23.
doi: 10.1002/1097-0142(19871115)60:10<2419::aid-cncr2820601011>3.0.co;2-s.

Effect of natural beta-interferon on cell proliferation and steroid receptor level in human breast cancer cells

G Sica  1 , V Natoli, C Stella, S Del Bianco
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Effect of natural beta-interferon on cell proliferation and steroid receptor level in human breast cancer cells

G Sica et al. Cancer. .

Abstract

The effect of natural beta-interferon (beta-IFN) on cell proliferation and steroid receptor level was investigated in CG-5 human breast cancer cell line. beta-interferon determines an appreciable diminution of cell growth, at concentrations ranging from 100 to 1000 IU/ml, which is enhanced when serum content of the culture medium is lowered. Low concentrations of beta-IFN (10-100 IU/ml) produce, after a 5-day treatment, an increase in estrogen receptors (ER) and progesterone receptors (PR). No variation of ER and PR levels is observed when beta-IFN is added directly to the cell homogenate before the assay. Our data suggest that beta-IFN could affect hormone sensitivity through a modification of ER and PR in neoplastic mammary cells.

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