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Review
. 2022 Dec 15:11:36.
doi: 10.12703/r/11-36. eCollection 2022.

New aspects of TGF-β superfamily signaling in development and disease (2022 FASEB meeting review)

Stuart J Newfeld  1 , Michael B O'Connor  2
Affiliations
Review

New aspects of TGF-β superfamily signaling in development and disease (2022 FASEB meeting review)

Stuart J Newfeld et al. Fac Rev. .

Abstract

The 13th Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference, "TGF-β superfamily signaling in development and disease" was convened at the Grand Hotel in Malahide, Ireland in July 2022. The Transforming Growth Factor-β (TGF-β) family of secreted proteins consists of agents of intercellular communication found in all multicellular animals. Attending the meeting was a diverse group of scholars with shared interests in understanding TGF-β signaling mechanisms, normal functions, and the diseases associated with misregulation and mutation. Despite intense study over the previous 35 years, new features of TGF-β activity continue to be discovered. This meeting report offers 21 investigator-provided summaries that illustrate the breadth of the thought-provoking presentations. An emerging theme of the meeting was the power of cross-disciplinary studies, such as one combining immunology, biochemistry, and structural biology, to unravel the secrets of parasitic TGF-β mimics. Please join us at the next meeting.

Keywords: Receptors; Smads; Structures; TGF-β; Therapeutics.

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Conflict of interest statement

The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Downtown Malahide near the Grand Hotel.
Figure 2.
Figure 2.. Malahide Harbor looking east toward the Irish Sea with the Grand Hotel on the right.
See this image and copyright information in PMC

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