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. 2023 Apr;8(4):907-911.
doi: 10.1016/j.ekir.2023.01.004. Epub 2023 Jan 9.

Rapid Waning of Immune Memory Against SARS-CoV-2 in Maintenance Hemodialysis Patients After mRNA Vaccination and Impact of a Booster Dose

Maxime Espi  1   2 , Xavier Charmetant  1   3 , Cyrille Mathieu  1 , Alexandre Lalande  1 , Didier Decimo  1 , Laetitia Koppe  2   4   5 , Caroline Pelletier  6 , Anne Ovize  7 , Alexia Barbry  7 , Emmanuel Morelon  3   5 , Emilie Kalbacher  6 , Denis Fouque  2   5 , Olivier Thaunat  1   3   5
Affiliations

Rapid Waning of Immune Memory Against SARS-CoV-2 in Maintenance Hemodialysis Patients After mRNA Vaccination and Impact of a Booster Dose

Maxime Espi et al. Kidney Int Rep. 2023 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Assessment of humoral and cellular immune responses directed against SARS-CoV-2 at memory phase. (a) Graphical representation of the study. Each symbol is an individual. The color code is, blue open triangles: vaccinated healthy volunteers; red open circle: vaccinated MHD patients; red dot: hybrid MHD patients. (b) Violin plots showing the individual values of the capacity of the sera collected at memory phase to neutralize the cytotoxicity of SARS-CoV-2 in vitro. The dotted line represents the limit of positivity of the test. Pie charts represent the proportion of positive patients in each group. Kruskal-Wallis test. (c) Evolution of anti-RBD IgG titers (BAU/ml) between the peak of the vaccine phase and the memory phase. (d) Correlation between the rate of decay of anti-RBD IgG titers and the value of anti-RBD IgG at the peak of vaccine phase. Spearman correlation coefficient. (e) Rate of decay of anti-RBD IgG titers (BAU/ml) between the peak of the vaccine phase and the memory phase. Median ± interquartile ranges. Kruskal-Wallis test. (f) Dot plots showing individual values of interferon-gamma releasing assay (IU/ml) at memory phase. Filled line represents the median of each group, and dotted line represents the threshold of positivity of the test. (g) Pie chart showing the distribution of patients according to the presence of the various immune effectors at memory phase in each groups. HV, healthy volunteers; MHD, maintenance hemodialysis; RBD, receptor-binding domain.
Figure 2
Figure 2
Immunogenicity of mRNA vaccine boost in MHD patients. (a) Graphical representation of the study. (b) Dot plots showing the individual values of anti-RBD IgG (BAU/ml) before and after the vaccine boost by half a dose (50 μg) of mRNA-1273 (left) or a full dose (30 μg) of BNT162b2 (right). Wilcoxon matched-pairs test. (c) Dot plots showing the neutralization titers before and after the vaccine boost by half a dose of mRNA-1273 (50 μg, left) or a full dose of BNT162b2 (30 μg, right). Wilcoxon matched-pairs test. Pie charts represents the proportion of positive patients. MHD, maintenance hemodialysis; RBD, receptor-binding domain.
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References

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