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Review
. 2022 Feb;115(1):23-31.
doi: 10.32074/1591-951X-814. Epub 2023 Jan 16.

WHO 2022 Classification of Kidney Tumors: what is relevant? An update and future novelties for the pathologist

Anna Caliò  1 , Stefano Marletta  1   2 , Matteo Brunelli  1 , Guido Martignoni  1   2
Affiliations
Review

WHO 2022 Classification of Kidney Tumors: what is relevant? An update and future novelties for the pathologist

Anna Caliò et al. Pathologica. 2022 Feb.

Abstract

Classification systems reflect our technical abilities in the investigation of tumors and our current theories on tumor development. Herein, by providing a historical perspective on the evolution of classifying renal tumors, we assess the current WHO classification highlighting the novelties and the implications of these changes in daily clinical practice.

Keywords: WHO; classification; clinical relevance; management; molecular; renal cell carcinoma; therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Flow diagram showing the evolution of the classification of renal cell tumor, with progressive implementation of newly recognized entities in the different editions of the AFIP and WHO blue books.
Figure 2.
Figure 2.
Several possible growth pattern of clear cell papillary renal cell tumor: papillary (A), tubular (B), cystic (C), tubular and cystic (D).
Figure 3.
Figure 3.
Various challenging morphological appearances of TFE3 and TFEB-rearranged renal cell carcinoma, respectively mimicking clear cell renal cell carcinoma (A), clear cell papillary renal tumor (B), papillary renal cell carcinoma (C), and renal oncocytoma (D).
Figure 4.
Figure 4.
Molecularly defined renal cell tumors: succinate dehydrogenase deficient renal cell carcinoma (A), fumarate hydratase deficient renal cell carcinoma (B), ALK-rearranged renal cell carcinoma (C), papillary neoplasm with inverted polarity (D).
Figure 5.
Figure 5.
Oncocytic renal tumors: eosinophilic solid and cystic renal cell carcinoma (A), low-grade oncocytic tumor (LOT) (B), eosinophilic vacuolated tumor (EVT) (C).
See this image and copyright information in PMC

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